Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 8, Problem 6Q
Summary Introduction

To review:

The reasons why glucose always enter the cells in the phosphorylated form.

Introduction:

Glucose enters the cell and gets converted into pyruvate through sequential reactions, generating energy and this process is known as glycolysis. After that, pyruvate is oxidized to carbon dioxide and water, generating enormous amount of energy. Glucose generally comes from the diet, but in case of starvation, there are other precursors for glucose.

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Von Gierke’s disease is a rare genetic disorder that results in a deficiency of glucose-6-phosphatase. Symptoms ketoacidosis, a buildup of glycogen in the liver, and lactate buildup.  Why does this glycogen storage disease not affect the brain? a) The brain is able to still perform glycolysis effectively b) None of the above c) In the event of hypoglycemia, the brain is able to utilize other sources of energy to produce ATP d) The brain is able to metabolize lactate, which is present in high concetrations.
Glucose binds to glycogen phosphorylase and competitively inhibits the enzyme. What is the physiological advantage of this?
Explain why triglycerides have a glucose-sparing effect.

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Biochemistry: The Molecular Basis of Life

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