Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Question
Chapter 8, Problem 20RQ
Summary Introduction
To review:
The reason behind which pyruvate is not oxidized to water and carbon dioxide under anaerobic situations.
Introduction:
During glycolysis, pyruvate is produced, which has different fates. In aerobic organisms, pyruvate gets converted into carbon dioxide and water, whereas in anaerobic organisms pyruvate gets converted into ethanol or lactate.
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The enzyme Malate Dehydrogenase (MD) catalyzes the conversion of malate to oxaloacetate using
nicotinamide adenine dinucleotide (NAD) as an enzyme cofactor (or coenzyme). Answer the following
questions about this reaction. See pp. 462-467 of your textbook for further information.
(a) Briefly explain how we know that this reaction (malate → oxaloacetate) is an oxidation-
reduction reaction.
(b) Write out the two reductive half reactions and indicate the ɛº' for each half reaction. Write out
the full balanced reaction for the malate to oxaloacetate reaction and indicate the Ae°l for the
reaction.
(c) What is the free energy change under standard state conditions (AGº') for this reaction? Which
direction is spontaneous?
Question 1: The overall process enabled by the glyoxylate cycle is:
(2acetyl-CoA) + (NAD+) + (2H2O) → (succinate) + (2CoA) + (NADH) + (2H+)
Dissect this process further by writing down all of the reactions that are actually involved in making one succinate from two acetyl-CoA units. Show chemical structure for all intermediates.
In the glyoxylate cycle, two molecules of acetyl-CoA areconverted into _______________ and malate.
Chapter 8 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 8 - Prob. 1QCh. 8 - Prob. 2QCh. 8 - Prob. 3QCh. 8 - Prob. 4QCh. 8 - Prob. 5QCh. 8 - Prob. 6QCh. 8 - Prob. 7QCh. 8 - Prob. 1RQCh. 8 - Prob. 2RQCh. 8 - Prob. 3RQ
Ch. 8 - Prob. 4RQCh. 8 - Prob. 5RQCh. 8 - Prob. 6RQCh. 8 - Prob. 7RQCh. 8 - Prob. 8RQCh. 8 - Prob. 9RQCh. 8 - Prob. 10RQCh. 8 - Prob. 11RQCh. 8 - Prob. 12RQCh. 8 - Prob. 13RQCh. 8 - Prob. 14RQCh. 8 - Prob. 15RQCh. 8 - Prob. 16RQCh. 8 - Prob. 17RQCh. 8 - Prob. 18RQCh. 8 - Prob. 19RQCh. 8 - Prob. 20RQCh. 8 - Prob. 21RQCh. 8 - Prob. 22RQCh. 8 - Prob. 23RQCh. 8 - Prob. 24RQCh. 8 - Prob. 25RQCh. 8 - Prob. 26RQCh. 8 - Prob. 27RQCh. 8 - Prob. 28RQCh. 8 - Prob. 29RQCh. 8 - Prob. 30RQCh. 8 - Prob. 31RQCh. 8 - Prob. 32RQCh. 8 - Prob. 33RQCh. 8 - Prob. 34RQCh. 8 - Prob. 35RQCh. 8 - Prob. 36RQCh. 8 - Prob. 37RQCh. 8 - Prob. 38RQCh. 8 - Prob. 39RQCh. 8 - Prob. 40FBCh. 8 - Prob. 41FBCh. 8 - Prob. 42FBCh. 8 - Prob. 43FBCh. 8 - Prob. 44FBCh. 8 - Prob. 45FBCh. 8 - Prob. 46FBCh. 8 - Prob. 47FBCh. 8 - Prob. 48FBCh. 8 - Prob. 49FBCh. 8 - Prob. 50SACh. 8 - Prob. 51SACh. 8 - Prob. 52SACh. 8 - Prob. 53SACh. 8 - Prob. 54SACh. 8 - Prob. 55TQCh. 8 - Prob. 56TQCh. 8 - Prob. 57TQCh. 8 - Prob. 58TQCh. 8 - Prob. 59TQCh. 8 - Prob. 60TQCh. 8 - Prob. 61TQCh. 8 - Prob. 62TQCh. 8 - Prob. 63TQCh. 8 - Prob. 64TQCh. 8 - Prob. 65TQCh. 8 - Prob. 66TQCh. 8 - Prob. 67TQCh. 8 - Prob. 68TQCh. 8 - Prob. 69TQCh. 8 - Prob. 70TQCh. 8 - Prob. 71TQCh. 8 - Prob. 72TQCh. 8 - Prob. 73TQ
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