Concept explainers
(a)
Interpretation:
Whether the citrate shuttle system is used in (1) the β-oxidation pathway, (2) ketogenesis, or (3) lipogenesis has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid. The fatty acid is synthesized in two parts. In the first part, there is citrate-malate shuttle system and in the second part, there is an acyclic process to synthesize saturated fatty acid.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acetyl CoA is degraded to acetyl CoA. This pathway is termed as β-oxidation pathway.
Ketogenesis is a
(b)
Interpretation:
Whether acetyl ACP is used in (1) the β-oxidation pathway, (2) ketogenesis, or (3) lipogenesis has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid. The fatty acid is synthesized in two parts. In the first part, there is citrate-malate shuttle system and in the second part, there is an acyclic process to synthesize saturated fatty acid.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acetyl CoA is degraded to acetyl CoA. This pathway is termed as β-oxidation pathway.
Ketogenesis is a metabolic process by which ketone bodies are produced by the breakdown of fatty acids and ketogenic amino acids. This metabolic process supplies organs with needed energy under certain circumstances such as starvation. Fatty acid molecules degrade into acetyl CoA which are utilized as reactants in the process of ketogenesis. acetyl CoA undergo the process of condensation twice, followed by chain cleavage and hydrogenation to produce ketone bodies.
(c)
Interpretation:
Whether H2O is used in (1) the β-oxidation pathway, (2) ketogenesis, or (3) lipogenesis has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid. The fatty acid is synthesized in two parts. In the first part, there is citrate-malate shuttle system and in the second part, there is an acyclic process to synthesize saturated fatty acid.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acetyl CoA is degraded to acetyl CoA. This pathway is termed as β-oxidation pathway.
Ketogenesis is a metabolic process by which ketone bodies are produced by the breakdown of fatty acids and ketogenic amino acids. This metabolic process supplies organs with needed energy under certain circumstances such as starvation. Fatty acid molecules degrade into acetyl CoA which are utilized as reactants in the process of ketogenesis. acetyl CoA undergo the process of condensation twice, followed by chain cleavage and hydrogenation to produce ketone bodies.
(d)
Interpretation:
Whether H2O is used as a reactant in (1) the β-oxidation pathway, (2) ketogenesis, or (3) lipogenesis has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid. The fatty acid is synthesized in two parts. In the first part, there is citrate-malate shuttle system and in the second part, there is an acyclic process to synthesize saturated fatty acid.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acetyl CoA is degraded to acetyl CoA. This pathway is termed as β-oxidation pathway.
Ketogenesis is a metabolic process by which ketone bodies are produced by the breakdown of fatty acids and ketogenic amino acids. This metabolic process supplies organs with needed energy under certain circumstances such as starvation. Fatty acid molecules degrade into acetyl CoA which are utilized as reactants in the process of ketogenesis. acetyl CoA undergo the process of condensation twice, followed by chain cleavage and hydrogenation to produce ketone bodies.
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General, Organic, and Biological Chemistry
- For each of the following, indicate whether the arrow pushes are valid. Do we break any rules via the arrows? If not, indicate what is incorrect. Hint: Draw the product of the arrow and see if you still have a valid structure. a. b. N OH C. H N + H d. e. f. مه N COHarrow_forwardDecide which is the most acidic proton (H) in the following compounds. Which one can be removed most easily? a) Ha Нь b) Ha Нь c) CI CI Cl Ha Ньarrow_forwardProvide all of the possible resonanse structures for the following compounds. Indicate which is the major contributor when applicable. Show your arrow pushing. a) H+ O: b) c) : N :O : : 0 d) e) Оarrow_forward
- Draw e arrows between the following resonance structures: a) b) : 0: :0: c) :0: N t : 0: بار Narrow_forwardDraw the major substitution products you would expect for the reaction shown below. If substitution would not occur at a significant rate under these conditions, check the box underneath the drawing area instead. Be sure you use wedge and dash bonds where necessary, for example to distinguish between major products. Note for advanced students: you can assume that the reaction mixture is heated mildly, somewhat above room temperature, but strong heat or reflux is not used. Cl Substitution will not occur at a significant rate. Explanation Check :☐ O-CH + Х Click and drag to start drawing a structure.arrow_forwardDraw the major substitution products you would expect for the reaction shown below. If substitution would not occur at a significant rate under these conditions, check the box underneath the drawing area instead. Be sure you use wedge and dash bonds where necessary, for example to distinguish between major products. Note for advanced students: you can assume that the reaction mixture is heated mildly, somewhat above room temperature, but strong heat or reflux is not used. Cl C O Substitution will not occur at a significant rate. Explanation Check + O-CH3 Х Click and drag to start drawing a structure.arrow_forward
- ✓ aw the major substitution products you would expect for the reaction shown below. If substitution would not occur at a significant rate under these conditions, check the box underneath the drawing area instead. Be sure you use wedge and dash bonds where necessary, for example to distinguish between major products. Note for advanced students: you can assume that the reaction mixture is heated mildly, somewhat above room temperature, but strong heat or reflux is not used. C Cl HO–CH O Substitution will not occur at a significant rate. Explanation Check -3 ☐ : + D Click and drag to start drawing a structure. © 2025 McGraw Hill LLC. All Rights Reserved. Terms of Use Privacy Cearrow_forwardPlease correct answer and don't used hand raitingarrow_forwardDon't used hand raiting and don't used Ai solutionarrow_forward
- Determine whether the following reaction is an example of a nucleophilic substitution reaction: Br OH HO 2 -- Molecule A Molecule B + Br 义 ollo 18 Is this a nucleophilic substitution reaction? If this is a nucleophilic substitution reaction, answer the remaining questions in this table. Which of the reactants is referred to as the nucleophile in this reaction? Which of the reactants is referred to as the organic substrate in this reaction? Use a ŏ + symbol to label the electrophilic carbon that is attacked during the substitution. Highlight the leaving group on the appropriate reactant. ◇ Yes O No O Molecule A Molecule B Molecule A Molecule B टेarrow_forwardPlease correct answer and don't used hand raitingarrow_forwardPlease correct answer and don't used hand raitingarrow_forward
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