Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 24, Problem 9P
Interpretation Introduction

Interpretation:

A structural or functional role for the O-linked saccharide domain in the LDL receptor should be suggested.

Concept Introduction:

The LDL receptor in cell membrane is consisted with 839 amino acid residues and has five domains. Two of them have multiple subdomains. LDL binding domain at the N-terminal has 7 cysteine rich repeats. Other segment contains three epidermal growth factor repeats and ß propeller module. This segment is followed by a 58-residue segment of O-linked oligosaccharides, membrane spanning segment and another 50-residue segment protruding into the cytosol. LDL particle binds to the fourth and fifth cysteine-rich repeats.

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