Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 24, Problem 9P
Interpretation Introduction
Interpretation:
A structural or functional role for the O-linked saccharide domain in the LDL receptor should be suggested.
Concept Introduction:
The LDL receptor in cell membrane is consisted with 839 amino acid residues and has five domains. Two of them have multiple subdomains. LDL binding domain at the N-terminal has 7 cysteine rich repeats. Other segment contains three epidermal growth factor repeats and ß propeller module. This segment is followed by a 58-residue segment of O-linked oligosaccharides, membrane spanning segment and another 50-residue segment protruding into the cytosol. LDL particle binds to the fourth and fifth cysteine-rich repeats.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Show the complete reaction mechanism for the deamination of alanine until the amino group is transferred to the keto acid acceptor ⍺-ketoglutarate
Please don't provide handwritten solution .....
In the majority of cases, amino acid catabolism can be broken down into a two-stepprocess; ‘transamination’ followed by ‘oxidative deamination’. Serine doesn’t followthis two-step process; fully explain the reaction and mechanism involved in thedegradation process used to form its α-keto acid.
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Incubation of the norsolinic acid synthase holo-ACP with malonyl CoA gave malonyl-S-ACP (molecular weight 10112 Da). (ACP SH holo-ACP Malonyl-SNAC Calculate the molecular weight of holo-ACP. (ACP OH malonyl-S-ACP MW = 10112arrow_forwardUsing the ActiveModel for phosphofructokinase (Trypanosoma), describe the difference between the APO1, AP02, and holoenzyme conformations.arrow_forwardWhen the identical subunits of chicken liver fatty acid synthase are dissociated in vitro, all of the activities can be detected in the separated subunits except for the β-ketoacyl synthase reaction and the overall synthesis of palmitate. Explain these observations.arrow_forward
- Consider the each of the amino acids in the peptide below. Ala-Ile-Asp-Arg-Gln-Gly-Pro-Gly-Ala-Tyr-Val-Ile-Gln-Leu If all of the amino acids are degraded to yield energy (ATP), explain how many Acetyl CoAs for oxidation to CO2 could be produced from this peptide. note: Do not make glucose at the beginning, however converting the TCA intermediates into molecules in the glycolytic pathway for optimal Acetyl CoA production is allowed. Be sure to show clearly which pathway will the Acetyl CoA enter (to yield ATP ultimately) under such conditionarrow_forwardesent ane to produce the sucrose is actually points) Consider a situation where valine was used by the liver for gluconeogenesis. Valine is metabolized via the following pathway. 2022, Arizona State University COA valine NH₂ COO CO₂ ATP HỌ NHỉ COA CO₂ COO NAD NADH NAD NADH COA H+ H FAD FADH2 r CO2 COA COA H₂O COO H COO NADH NAD+ H HOT GTP GDP HOT P₁ COA ADP+ P COA COO COA Coo succinyl CoA How many molecules of valine would be required for one molecule of glucose? Using the appropriate amount of valine determined above, how many NADH, FADH2, and ATP would be produced or consumed by the conversion of valine into glucose? Assume that any net production of NADH and FADH2 is used in electron transport. What is the maximum net ATP production in the human mitochondria (10 c subunits)? Don't forget to add/subtract the ATP determined in the above question.arrow_forwardLactate dehydrogenase is a tetramer of MW 134000 g/mole composed of subunits which are equal in size. It is found in the cytoplasm of eukaryotic and prokaryotic cells. Describe the secondary, tertiary and quaternary structures of lactate dehydrogenase.arrow_forward
- Match the letter structures to the given description.arrow_forwardIn germ-free mice, which harbor no intestinal bacteria, the O-linked oligosaccharides of intestinal glycoproteins tend to lack a terminal fucose residue (see Fig.). (a) What enzyme is not produced in normal quantities in these mice? (b) What monosaccharides tend to appear at the ends of O-linked oligosaccharides in these animals?arrow_forwardConsider the role of Histidine in the Serine protease mechanism and sketch a plot showing the predicted pH profile of chymotrypsin which has a pH optimum of approximately ~8. The pk, for the His in the catalytic triad is 7.3 in free chymotrypsin which increases to greater than 8 with a bound peptide. Be sure to label the plot axes and indicate the pka of His on the plot,arrow_forward
- Thiolase is homologous in structure to the condensing enzyme. On the basis of this observation, propose a mechanism for the cleavage of 3-ketoacyl CoA by CoA.arrow_forwardBased on your understanding of the structure and function of the enzyme chymotrypsin, explain why proteolytic activation by Trypsin in the intestine is required for chymotrypsin to bind its substrates with high affinity. Your answer should include a description of the amino acid residue or residues involved AND a kinetic experiment that suggested this.arrow_forwardThe end products of tryptophan degradation are acetyl CoA and acetoacetyl CoA, yet tryptophan is a gluconeogenic amino acid in animals. Explain.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY