Interpretation:
Interactions in LDL receptor should be identified.
Concept Introduction:
LDL receptor has five domains. N terminal LDL binding domain contains seven cysteine rich repeats referred as R1 to R7. Next epidermal growth factor repeats and ß propeller module can be found. Those segments are followed by O-linked oligosaccharide, a membrane spanning segment and another segment extended towards the cytosol. LDL particles bind with R4 and R5 cysteine repeats. At low pH, the LDL receptor polypeptide folds so that ß propeller domain is associated with R4 and R5 displacing the LDL particle. These two repeats contain two loops connected by 3 disulfide bonds. Second loop of each repeat have Asp and Glu acidic residues and acts as a Ca2+ binding site.
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Biochemistry
- Amino acid alaninearrow_forwarddistribution of Benzene in a 4-compartment PBK model after an exposure of 6h. Convert Berkeley Madonna code to Matlab. Note: The parameters in the table below are for a mouse model. 1a) What are the two type of products containing Benzene consumers were recently concerned about. Which of these two different type of products is likely more harmful? (hint: check news/reports and social media channels) 1b) Plot Jresp along with the concentrations of Benzene in blood, fat, non-fat and liver in a 24h window (pdf). Why is Jresp slightly decreasing within 6h of exposure? Here is the Berkeley Madonna code: {Top model} METHOD RK4 STARTTIME = 0 STOPTIME = 24 DT = 0.02 {Reservoirs Blood, Fat, NonFat and Liver} d/dt (NF) = + Jnf INIT NF = 0 d/dt (F) = + Jf INIT F = 0 d/dt (B) = - Jnf - Jf - Jl + Jresp INIT B = 0 d/dt (L) = + Jl - Jmetab INIT L = 0 {Flows} Jnf = Qnf*(Cb-Cnf) Jf = Qf*(Cb-Cfv) Jl = Ql*(Cb - Clv) Jmetab = vmax*Cl/(Km +…arrow_forwardMake an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shown.(from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues ) with labelarrow_forward
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- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning