Interactions in LDL receptor should be identified. Concept Introduction: LDL receptor has five domains. N terminal LDL binding domain contains seven cysteine rich repeats referred as R1 to R7. Next epidermal growth factor repeats and ß propeller module can be found. Those segments are followed by O-linked oligosaccharide, a membrane spanning segment and another segment extended towards the cytosol. LDL particles bind with R4 and R5 cysteine repeats. At low pH, the LDL receptor polypeptide folds so that ß propeller domain is associated with R4 and R5 displacing the LDL particle. These two repeats contain two loops connected by 3 disulfide bonds. Second loop of each repeat have Asp and Glu acidic residues and acts as a Ca 2+ binding site.

Question

Want to see the full answer?

Answer 1

Question

Chapter 24, Problem 17P

Interpretation Introduction

Interpretation:

Interactions in LDL receptor should be identified.

Concept Introduction:

LDL receptor has five domains. N terminal LDL binding domain contains seven cysteine rich repeats referred as R1 to R7. Next epidermal growth factor repeats and ß propeller module can be found. Those segments are followed by O-linked oligosaccharide, a membrane spanning segment and another segment extended towards the cytosol. LDL particles bind with R4 and R5 cysteine repeats. At low pH, the LDL receptor polypeptide folds so that ß propeller domain is associated with R4 and R5 displacing the LDL particle. These two repeats contain two loops connected by 3 disulfide bonds. Second loop of each repeat have Asp and Glu acidic residues and acts as a Ca²⁺binding site.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

JOB UPDATE Apply on- COMPANY Vinkjobs.com @ OR Search "VinkJobs.com" on Google JOB PROFILE JOB LOCATION ACCENTURE APPLICATION DEVELOPMENT MULTIPLE CITIES HITACHI FULL STACK DEV BENGALURU PAYU BUSINESS ANALYST MULTIPLE CITIES MEESHO DATA SCIENTIST BENGALURU ORACLE SOFTWARE ENGINEER BENGALURU LUMEL FRONT END DEVELOPER CHENNAI MPHASIS INKLE TECH SUPPORT ENGINEER BENGALURU CUSTOMER SUPPORT BENGALURU MAKE MY TRIP KEY ACCOUNT MANAGER AMAZON DATA ASSOCIATE DELHI NCR BENGALURU

stripe.perplexity.ai/p + ← Return to Perplexity Al, Inc perplexity CURRENT SUBSCRIPTION 13 13 Perplexity Pro $0.00 per month View details Your subscription ends on January 28, 2026.

You’ve isolated a protein and determined that the Native molecular weight of the holoenzyme is 160 kD using size exclusion chromatography. Analysis of this protein using SDS-PAGE revealed 2 bands, one at 100 kD and one at 30 kD. The enzyme was found to be 0.829% NAD (by weight). What further can be said regarding the structure of the polypeptide?