Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 24, Problem 15P
Interpretation Introduction
Interpretation:
A suitable mechanism for the ß-ketoacyl ACP synthase reaction should be written showing how the involvement of malonyl CoA drives this reaction forward.
Concept Introduction:
In fatty acid synthesis, condensation of acetyl CoA and malonyl CoA is driven by condensation. This decarboxylative condensation of acyl group with malonyl ACP to produce a ß ketoacyl-ACP intermediate is catalyzed by ß ketoacyl ACP synthase.
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Considering the complete oxidation of an 18-C fatty acid. Give the answer to the following question.a. What is the total number of NADH produced in TCA if all of the acetyl CoA enters the cycle?
b. What is the total number of FADH2 produced in TCA if all the acetyl CoA enters the cycle?c. How much ATP is produced in the overall oxidation?
Another biochemical study from another patient reveals a 100X increase in the KM value for the enzyme succinyl-CoA synthetase for this individual (only isozyme expressed). What metabolic and physiological consequences would you predict resulting from this enzymatic change?
Succinyl-CoA Synthetase mechanism
Succinyl-CoA synthetase
enzyme active site
O Substrates bind
to the active site
COO
of succinyl-CoA
synthetase
CH2
OH
His
CH2
. Succinyl-CoA
COA-
Guanosine
Phosphoryl group
transfer to GDP to
form GTP, which is
released from the
2 Formation of
succinyl-phosphate
COA
GTP
enzyme
Formation of
phosphohistidine
Guanosine
COO
Phosphohistidine
CH2
GDP
GDP
CH2
COO
CH2
| "Succinate
CH,
Succinyl-phosphate
ČOO
a) Which catalytic mechanism occurs in step 2?
b) Why must phosphate first bind to succinyl-CoA before interacting with the His site and GDP?
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
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