Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 24, Problem 15P
Interpretation Introduction
Interpretation:
A suitable mechanism for the ß-ketoacyl ACP synthase reaction should be written showing how the involvement of malonyl CoA drives this reaction forward.
Concept Introduction:
In fatty acid synthesis, condensation of acetyl CoA and malonyl CoA is driven by condensation. This decarboxylative condensation of acyl group with malonyl ACP to produce a ß ketoacyl-ACP intermediate is catalyzed by ß ketoacyl ACP synthase.
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Another biochemical study from another patient reveals a 100X increase in the KM value for the enzyme succinyl-CoA synthetase for this individual (only isozyme expressed). What metabolic and physiological consequences would you predict resulting from this enzymatic change?
Succinyl-CoA Synthetase mechanism
Succinyl-CoA synthetase
enzyme active site
O Substrates bind
to the active site
COO
of succinyl-CoA
synthetase
CH2
OH
His
CH2
. Succinyl-CoA
COA-
Guanosine
Phosphoryl group
transfer to GDP to
form GTP, which is
released from the
2 Formation of
succinyl-phosphate
COA
GTP
enzyme
Formation of
phosphohistidine
Guanosine
COO
Phosphohistidine
CH2
GDP
GDP
CH2
COO
CH2
| "Succinate
CH,
Succinyl-phosphate
ČOO
a) Which catalytic mechanism occurs in step 2?
b) Why must phosphate first bind to succinyl-CoA before interacting with the His site and GDP?
The total degradation of a fatty acid with an odd number of carbons yields acetyl-CoA and another compound, X. Show the structure of X, and describe the pathway by which it is converted into a citric acid cycle intermediate, including where any cofactors participate.
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
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