Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 24, Problem 8P
Interpretation Introduction
Interpretation:
Tracing each of the carbon atoms of mevalonate through the synthesis of cholesterol, the source (that is the position in the mevalonate structure) of each carbon in the final structure should be determined.
Concept Introduction:
The first step of cholesterol biosynthesis is Claisen condensation of two molecules of acetyl-CoA to form acetoacetyl CoA which is catalyzed by ß ketothiolase. Next acetyl-CoA and acetoacetyl-CoA combine to form HMG-CoA which is catalyzed by HMG-CoA synthase. This HMG-CoA undergoes two NADPH dependent reductions to form 3R mevalonate. This is the rate limiting step of cholesterol biosynthesis. This mevalonate is converted to squalene after various steps in between. Squalene is then converted to squalene-2,3-
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Reaction mechanism for the transamination of alanine based on this figure.
The conversion of glucose-6-phosphate to fructose-6-phosphate in the glycolytic pathway (Choose
all that apply)
O positions a carbonyl group on carbon 2 of fructose-1-phosphate
O positions an amino group NH2 on carbon 3 of fructose-1-phosphate
O positions a carbonyl group on carbon 3 of fructose-1-phosphate
O is an aldose-keto isomerization
O positions a primary alcohol function at carbon C-1 that facilitates phosphorylation of fructose-6-phosphate
O is a keto-aldose isomerization
O positions an amino group NH2 on carbon 2 of fructose-1-phosphate
Malonyl-ACP is a precursor in fatty acid synthesis in the acyl carrier protein pathway. Draw the structure of malonyl-ACP
No stereochemistry required
Represent ACP by R1
and be sure to include charges on atoms at ph=7
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Explaining the Stoichiometry of Fatty Acid Synthesis Carefully count and account for each of the atoms and charges in the equations for the synthesis of palmitoyl-CoA, the synthesis of malonyl-CoA, and the overall reaction for the synthesis of palmitoyl-CoA from acetyl-CoA.arrow_forwardUnderstanding the Stoichiometry of Cholesterol Synthesis Write a Balanced, stoichiometric reaction for the synthesis of cholesterol from acetyl-CoA.arrow_forwardTracing Carbon Atom Incorporation in Fatty Acids (Integrates with Chapters 18 and 19.) Use the relationships shown in Figure 24.1 to determine which carbons of glucose will be incorporated into palmitic acid. Consider the cases of both citrate that is immediately exported to the cytosol following its synthesis and citrate that enters the TCA cycle.arrow_forward
- 1,2-dioleoyl-3-myristyl-sn-glycerolsn-16:0-12:0-16:0LLnO Consider the TAGS abovea. Which is most prone to lipid oxidation? Explain.b. Which has the highest melting point? Explain.c. Which will most likely convert fastest to the most stable polymorphic form. Explain.arrow_forwardMake an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shown.(from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues ) with labelarrow_forwardGive detailed Solution with explanation needed (no need Handwritten answerarrow_forward
- Question 13 of 40 0% Identify the true characteristic of glutamate at its isoelectric point (pI). 00% The net charge of glutamate is positive. prrect The side chain of glutamate has a negative charge. L00% In an electric field, glutamate migrates toward the anode. orrect The net charge of glutamate is zero. 0% In an electric field, glutamate migrates toward the cathode. 0% Determine the pl of glutamate given its pK at each charge state. Give your answer to two decimal places. Progress Charge: 1+ 1- 2- 0% H,N- CHCO, CH, *H,N-CHCO,H *H,N-CHCO, *H,N–CHCO, CH, CH, pK = 9.67 CH, CH, pK = . = 4.25 0% pk = 2.19 CH, CH, CH, C=0 C=0 C=0 Ć=0 0% MacBook Pro Q Search Default Search &arrow_forwardBiosynthesis of fatty acid 20:D6 from acetyl-CoA occurs in the __________ of mammalian cells. Cytosol Endoplasmic reticulum Both A and B Neither A nor B Assuming all three carbon atoms of glycerol are labeled as C14 radioisotopes and the radioisotope-labeled glycerol undergoes metabolism in animals. All of the following molecules in the animal maycontain C14 radioisotopes EXCEPT: Pyruvate Acetyl-CoA Glutamine Fatty acids Oxaloacetate All of the above molecules may contain C14 radioisotopearrow_forward7.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY