Free energy Energy barrier without enzyme Energy barrier with enzyme E + S ES E + P EP Reaction coordinate FIGURE 30-2 Enzyme-catalyzed reaction Prior to the reaction taking place, the separated enzyme (E) and substrate (S) bind to form an enzyme-substrate complex (ES). The reaction forms an initial enzyme-product complex (EP), after which the free product (P) is released. The enzyme-catalyzed reaction has a lower energy barrier than the uncatalyzed reaction. E+SE ES EP: E+P (30-1)

Free energy Energy barrier without enzyme Energy barrier with enzyme E + S ES E + P EP Reaction coordinate FIGURE 30-2 Enzyme-catalyzed reaction Prior to the reaction taking place, the separated enzyme (E) and substrate (S) bind to form an enzyme-substrate complex (ES). The reaction forms an initial enzyme-product complex (EP), after which the free product (P) is released. The enzyme-catalyzed reaction has a lower energy barrier than the uncatalyzed reaction. E+SE ES EP: E+P (30-1)

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 23P

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