A.Piefly summarize the process of transcription. Include in your summary a list of at least 2proteins that are involved in transcription. Your summary should be 2-3 sentences long.B. Pyrrole-imidazole polyamides such as the ones discussed in this paper are designed to bindspecific sites on DNA. These types of polyamides can be used to inhibit transcription.a. Explain in 1-2 sentences how a molecule that binds to a specific DNA sequencecould inhibit transcription.b. Many types of cancer are caused by problems with transcription. Explain in 1-2sentences why a molecule like a polyamide would be better for treating a cancercaused by mis-regulations in transcription than a molecule that inhibits thefunctionality of RNA polymerase II. (Hint, think about side effects).C.A chemist made a similar molecule but rather than using pyrroles and imidazoles,they just used cyclopentane molecules. Would this molecule bind DNA asefficiently as the original polyamide? Explain your answer in 1-2 sentences.

B. Pyrrole-imidazole polyamides such as the ones discussed in this paper are designed to bind…

Answered: A. Piefly summarize the process of…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

a. In your claim words, depict the contrast between ρ-dependent and ρ-independent end of translation in prokaryotes. b. If you have a given amino acid, can you be able to identify its RNA? Why or why not? c. How does mutation can affect the central dogma and the phenotype?
The chart below is a position specific scoring matrix (PSSM, a logarithmic transformed matrix) for a transcription factor binding site. (1). Evaluate a sequence “GACATTCA” to find out which segment of the sequence fits the binding site best. (2) What is the max score that a sequence can have with this PSSM? (3) What is the minimum score a sequence can have with this PSSM?
Give only typing answer with explanation and conclusion
Choose one of the strands and transcribe the strand. Show the steps (with proper label) and do a post transcriptional processing Once the transcript is made, do the process of translation. Again follow the steps. Use the Wobble Table for reference 5’ CTATATTTATGTGCTATATCCAGGACTGCCCCTAGGAAATAAAAAA…AAAAAAA 3’3’ GATATAAATACACGATATAGGTCCTGACGGGGATCCTTTATTTTTT…TTTTTTT 5’
Predict the state of transcription activation in the following scenarios: A. Regulated as usual B. Higher levels of transcription C. Lower levers of transcription Everything in the system is intact except activators can no longer bind to chromatin modifiers Everything in the system is intact except there are overly active histone deacetylases Everything in the system is intact except heterochromatin is constantly shifted to the form of euchromatin Everything in the system is intact except the main coactivator Mediator no longer binds to RNA Polymerase II
Discuss and make a list of the similarities and differences in theevents that occur during the initiation, elongation, and terminationstages of transcription and translation.
Ff.252.
Consider the Rho-dependent terminator sequence 5’CCCAGCCCGCCUAAUGAGCGGCCUUUUUUUU-3’. What affect would a point mutation at any one of the bolded and underlined nucleotides disrupt termination of transcription? Group of answer choices 1.Mutation in one of these nucleotides would disrupt base pairing, but not affect the formation of the hairpin and termination proceeds. 2.Mutation in one of these nucleotides would have no affect on base pairing, so the termination hairpin is formed and termination proceeds. 3.Mutation in one of these nucleotides would not disrupt base pairing, but would prevent the formation of the hairpin and disrupt termination. 4.Mutation in one of these nucleotides would disrupt base pairing, preventing the formation of the hairpin and disrupting termination.
Consider this list (below) of steps involved in transcription. These steps are out of order. TRANSCRIPTION: 1. mRNA travels through a nuclear pore and enters the cytoplasm 2. the mRNA polymerase attaches at the start of a specific gene 3. RNA polymerase reads the gene surface4. a transcription factor bonds to a promoter site5. DNA molecule is unwound 6. a complimentary mRNA is produced What is the correct order of this transcription?
a. A single mutation in the riboswitch’s sequence changes the ligand binding specificity from guanine toadenine. Predict what single mutation could be made in the guanine-responsive riboswitch sequenceto convert it to an adenine-responsive riboswitch. Justify your answer b. Could a DNA molecule with the same nucleotide sequence as the guanine-responsive riboswitch bindguanine in a similar manner as the RNA-based molecule? Explain
Briefly explain the importance of the protein factor EF-Ts in the translation process. Do not simply define the given.
Name four major classes of DNA-binding proteins that are responsible for controlling transcription, and describe their structural features.

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