Question 3. You are a pharmacist and have come across a prescription for simvastatin. Upon checking the patient's current medication list, you see that the patient is also taking erythromycin which is a strong CYP3A4 inhibitor. Based on your knowledge of how these drugs are metabolized, explain how drug-drug interaction via enzyme inhibition will affect the steady state and side effects of these drugs in the body.

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter22: Medications Used For Gastrointestinal System Disorders
Section: Chapter Questions
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Question 3.
You are a pharmacist and have come across a prescription for simvastatin. Upon checking the
patient's current medication list, you see that the patient is also taking erythromycin which is a
strong CYP3A4 inhibitor. Based on your knowledge of how these drugs are metabolized, explain
how drug-drug interaction via enzyme inhibition will affect the steady state and side effects of
these drugs in the body.
Transcribed Image Text:Question 3. You are a pharmacist and have come across a prescription for simvastatin. Upon checking the patient's current medication list, you see that the patient is also taking erythromycin which is a strong CYP3A4 inhibitor. Based on your knowledge of how these drugs are metabolized, explain how drug-drug interaction via enzyme inhibition will affect the steady state and side effects of these drugs in the body.
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