Molecule A held promise as a treatment for rheumatoid arthritis except that it remained in the body for too long (~120 hours in rat models). Suggest a minor modification you could make to increase the rate at which it might be metabolized and therefore excreted by the body. [If you can solve this problem, you will have invented the drug Celebrex®.] Cl. O=S= H₂N O A -CF3 Celebrex
Molecule A held promise as a treatment for rheumatoid arthritis except that it remained in the body for too long (~120 hours in rat models). Suggest a minor modification you could make to increase the rate at which it might be metabolized and therefore excreted by the body. [If you can solve this problem, you will have invented the drug Celebrex®.] Cl. O=S= H₂N O A -CF3 Celebrex
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![Molecule A held promise as a treatment for rheumatoid arthritis except that it
remained in the body for too long (~120 hours in rat models). Suggest a minor modification you
could make to increase the rate at which it might be metabolized and therefore excreted by the
body. [If you can solve this problem, you will have invented the drug Celebrex®.]
Cl.
O=S=
H₂N
O
A
-CF3
Celebrex](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F3da4bca4-973e-4c76-a119-0962478a5a75%2F339f85af-79b0-43f9-a927-5f6d67d148b0%2For6gv8_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Molecule A held promise as a treatment for rheumatoid arthritis except that it
remained in the body for too long (~120 hours in rat models). Suggest a minor modification you
could make to increase the rate at which it might be metabolized and therefore excreted by the
body. [If you can solve this problem, you will have invented the drug Celebrex®.]
Cl.
O=S=
H₂N
O
A
-CF3
Celebrex
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