Given the active site diagram and reaction mechanism, indicate the mechanism of irreversible inhibition for the inhibitor provided. HO OH OH Active Site "HN NH N NH Non-specific inhibition HO Uncompetitive inhibition Affinity-based inhibition Transition state analog OH OH Mechanism-based inhibition Reaction Mechanism "HN NH [attises -P₁ OOH HO HO OH OH OH OH OH Inhibitor
Given the active site diagram and reaction mechanism, indicate the mechanism of irreversible inhibition for the inhibitor provided. HO OH OH Active Site "HN NH N NH Non-specific inhibition HO Uncompetitive inhibition Affinity-based inhibition Transition state analog OH OH Mechanism-based inhibition Reaction Mechanism "HN NH [attises -P₁ OOH HO HO OH OH OH OH OH Inhibitor
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![Given the active site diagram and reaction mechanism, indicate the mechanism of
irreversible inhibition for the inhibitor provided.
HO
OH
OH
NH
Active Site
*HN NH
NH
HO
Uncompetitive inhibition.
Non-specific inhibition.
Affinity-based inhibition
Transition state analog
OH
OH
o[
Mechanism-based inhibition
Reaction Mechanism
NH
HN ΝΗ
OH
OH
[at] ut
OH
-P₁
OH
HO
OOH
HO
OH
Inhibitor](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe48f5f36-4844-484b-9d30-27dc6c678b4b%2F33836feb-28be-44b5-8555-1e2321e4f000%2Fey85dxi_processed.png&w=3840&q=75)
Transcribed Image Text:Given the active site diagram and reaction mechanism, indicate the mechanism of
irreversible inhibition for the inhibitor provided.
HO
OH
OH
NH
Active Site
*HN NH
NH
HO
Uncompetitive inhibition.
Non-specific inhibition.
Affinity-based inhibition
Transition state analog
OH
OH
o[
Mechanism-based inhibition
Reaction Mechanism
NH
HN ΝΗ
OH
OH
[at] ut
OH
-P₁
OH
HO
OOH
HO
OH
Inhibitor
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