Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 24, Problem 16P
Interpretation Introduction
Interpretation:
Examination required for the mammalian FAS structure and determination for the distance between several functional sites.
Concept introduction:
FAS i.e. Fatty acid synthetase is a multi-enzyme protein which catalyzes fatty acid synthesis.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Consider the role of Histidine in the Serine protease mechanism and sketch a plot showing
the predicted pH profile of chymotrypsin which has a pH optimum of approximately ~8. The pk,
for the His in the catalytic triad is 7.3 in free chymotrypsin which increases to greater than 8 with
a bound peptide. Be sure to label the plot axes and indicate the pka of His on the plot,
Amino acid alanine
De novo purine biosynthesis is a 10-step pathway that builds the purine rings one atom, or one group of atoms, at a time. The
pathway converts 5-phosphoribosyl-1-pyrophosphate (PRPP) to inosine monophosphate (IMP).
Identify the nine intermediates on the pathway diagram.
5-phosphoribosyl-1-amine
PRPP
glycinamide ribonucleotide
formylglycinamide
rimuclocticke
N-succinyl-5-aminoimidazole-4-
carboxamide ribonucleotide
5-aminoimidazole-4-
carboxamide ribonucleotide
Incorrect
-CH,
H
H
OH
Gn
Glu
-CH.
H
0.
CH H
glycine + ATP
HN
HC
HC
ADP+P
OH
OH OH
0
-PFI
HN
(P-Ribose
Formy-THF
HN
THE
H
HN
-Ribose
-ATP
6-Ⓡ
CH₂
HN
HC CH,
P-Ribose
-ATP
ADP+P
NH,
ADP+P
HN NH
-Ribose
NH,
N-formylaminoimidazole-4-
carboxamide ribonucleotide
formylglycinamidine
ribonuclcotide
S-aminoimidazole
ribonuclotidie
ATP ADP+Pi
HCO,
carboxyanincimidazole
ribonucleotide
-Ribose
H
-Ribose
H₂O
Formyl-THF-
ASP
Fumarate
HC
THE
0
N.
"NH₂
Ⓒ-Abse
NH,
NH,
-ATP
NH
-N-CH
COO
ADP+PI
Coo
IMP
COO
NH,
000
Answer Bank
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Malonyl-ACP is a precursor in fatty acid synthesis in the acyl carrier protein pathway. Draw the structure of malonyl-ACP No stereochemistry required Represent ACP by R1 and be sure to include charges on atoms at ph=7arrow_forwardDrawing the Structure of a Glycopeptide (Integrates with Chapters 4and 5.) Consider the peptide DGNILSR, where N has a covalentlylinked galactose and S has a covalently linked glucose. Draw thestructure of this glycopeptide, and also draw titration curves for theglycopeptide and for the free peptide that would result from hydrolysis of the two sugar residues.arrow_forwardBiosynthesis of fatty acid 20:D6 from acetyl-CoA occurs in the __________ of mammalian cells. Cytosol Endoplasmic reticulum Both A and B Neither A nor B Assuming all three carbon atoms of glycerol are labeled as C14 radioisotopes and the radioisotope-labeled glycerol undergoes metabolism in animals. All of the following molecules in the animal maycontain C14 radioisotopes EXCEPT: Pyruvate Acetyl-CoA Glutamine Fatty acids Oxaloacetate All of the above molecules may contain C14 radioisotopearrow_forward
- The enzyme lysozome catalysis the hydrolysis of polymer that consists of N-acetylglucosamine and N-acetylmuramic. This reaction usually takes place at ph=5 but is dramatically inactive above ph=7. Explain why this occurs referring to the catalytic mechanism of lysozomearrow_forwardGlobular proteins with multiple disulfide bonds must be heated longer and at higher temperature to denature them. Bovinepancreatic trypsin inhibitor (BPTI), having 58 amino acids in a single chain and 3 disulfide linkages, loses its catalytic activity whenheated at nearly 90°C for 5-10 minutes. Explain the molecular basis of this observed thermal property of BPTI relative to the nativestructure and function of the protein. please do not copy from other answers herearrow_forwardFructose 1,6-bisphosphatase (FBPase) is a key enzyme in gluconeogenesis. The mammalian enzyme is tetrameric, negatively regulated by both Fructose 2,6-bisphosphate and AMP. Propose three (3) distinct models for how these molecules regulate FBPase activity. Also, describe how the enzyme might differentiate between Fructose 1,6 bisphosphate and Fructose 2,6-bisphosphate binding to the allosteric site on the enzyme with particular emphasis on amino acids comprising the allosteric binding site(s).arrow_forward
- Globular proteins with multiple disulfide bonds must be heated longer and at higher temperature to denature them. Bovinepancreatic trypsin inhibitor (BPTI), having 58 amino acids in a single chain and 3 disulfide linkages, loses its catalytic activity whenheated at nearly 90°C for 5-10 minutes. Explain the molecular basis of this observed thermal property of BPTI relative to the nativestructure and function of the protein. do not coy from other answers herearrow_forwarda molecule that lowers cholesterol levels in humans interacts with the enzyme HMA-COG reductase. how do you describe their interaction biochemically? what experiment would you do?arrow_forwardIncubation of the norsolinic acid synthase holo-ACP with malonyl CoA gave malonyl-S-ACP (molecular weight 10112 Da). (ACP SH holo-ACP Malonyl-SNAC Calculate the molecular weight of holo-ACP. (ACP OH malonyl-S-ACP MW = 10112arrow_forward
- Globular proteins with multiple disulfide bonds must be heated longer and at higher temperature to denature them. Bovinepancreatic trypsin inhibitor (BPTI), having 58 amino acids in a single chain and 3 disulfide linkages, loses its catalytic activity whenheated at nearly 90°C for 5-10 minutes. Explain the molecular basis of this observed thermal property of BPTI relative to the nativestructure and function of the protein.arrow_forwardDuring the process of synthesizing palmitate (C16), an acyl ACP __________. For the sake of this question, don’t treat acetyl ACP or malonyl ACP as an acyl ACP; assume the acyl ACP is a product at least 4 carbons long. Choose ALL that apply. (A) can be condensed with malonyl ACP to produce a Cn+2 b-ketoacyl ACP (B) is formed from the reduction of a trans D2-enoyl ACP(C) is a product of acetyl transacylase(D) is reduced by NADPH (E) is a substrate for b-ketoacyl synthase(F) can be condensed with acetyl ACP to produce a Cn+2 b-ketoacyl ACParrow_forwardEnzyme: Crystal Structure of Wild-Type Human Phosphoglucomutase-1 (PGM1) the description of the mechanism of how this enzyme is regulated (e.g., depending on the enzyme, the mechanism could range from being solely dependent on gene regulation to protein structure-based mechanism).arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY