Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 24, Problem 24P
Interpretation Introduction

Interpretation:

Using the active model for HMG-CoA reductase (HMGR), how HMGR is regulated and why do researchers seek ways to inhibit HMGR should be explained.

Concept Introduction:

HMG-CoA reductase is the rate controlling enzyme of mevalonate pathway which is the pathway for cholesterol and another isoprenoid biosynthesis. HGMR has eight domains and it is embedded in endoplasmic reticulum membrane. Today most of the cholesterol lowering drugs targets this enzyme. HMGR catalyzes the formation of mevalonic acid.

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