Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 24, Problem 5P
Interpretation Introduction

Interpretation:

Stoichiometry of the stearoyl-CoA desaturase should be convinced correct.

Concept Introduction:

In eukaryotes, addition of double bond to fatty acids does not occur until the fatty acid chain occupied its full length. But the dehydrogenation of stearoyl-CoA occurs in the middle of the chain

  Stearoyl-CoA + NADH + H+ + O2 Oleoyl-CoA + 2 H2O

Above reaction is catalyzed by stearoyl-CoA desaturase enzyme. This enzyme has a nonheme iron center. NADH and O2 is required to run this reaction. As well as, two other proteins cytochrome b5 reductase and cytochrome b5 are needed. These three proteins are incorporated with ER membrane.

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