Answered: B) You have isolated a mutant cell line…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Below are data from Jimenez et al (2022) depicting cellular expression patterns of the tumor suppressor transcription factor p53 (a gene commonly mutated in cancers). They explored oscillating expression patterns found in a mutated human cell line. Panel D shows measurements of changes in p53 mRNA levels measured using two different approaches; figure E shows measurements of protein levels from the same samples. The numbers on either side indicate the observed fold change (FC) in relative abundance of these molecules (note that any difference in values obtained between the two methods are not relevant for this question).

Answer part b as pictured in the question

RNASeq FC
1.5
1
0.5
p53
Mutant
1.5
1
0.5
0 1 2 3 4 5 6789
time [h]
p53
50
40
EM
30
20
1
0 1 2 3 4 56789
time [h]
40
30
20
B) You have isolated a mutant cell line which displays the above patterns in
p53 expression (again, mRNA on the left, protein on the right). Two
mutations were found in the p53 gene region; one that impacts the increase
in p53 protein amounts, and one that impacts the decline. Propose a
hypothesis for which general feature(s) of the gene region might be affected
by each of these changes, and briefly justify the change.

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