Briefly describe how mitotic recombination can result in loss of heterozygosity (LOH) at tumor suppressor gene loci.

Q: QUESTION 8 Which of the following is true of the RAS proto-oncogene? O Mutations involving RAS are…

A: Mutations are alterations in the DNA sequence of an organism. Small changes, such as adding or…

Q: Personalized cancer treatments involve identifying specific pathways in an individual tumor and…

A: Introduction Cancer is defined as a condition which is characterised by uncontrolled mitosis. In…

Q: rms of the cell cycle, what would happen if there was a defect in the Rb prote made it unable to…

A: Rb protein is a tumor suppressor protein that is it suppresses the tumor from growing. Hence Rb…

Q: Part 3C: Below is data from a pedigree trace of patients affected with mouse model of pancreatic…

A: Answer  The mode of inheritance shown in the above pedigree is of autosomal recessive

Q: The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene…

A: An oncogene is a type of gene that is responsible for causing the cells to divide uncontrollably and…

Q: Please answer  A mutation within an enhancer sequence regulating the expression of the ABC1 gene…

A: The transcription is the process by the RNA is produced from the DNA and this is the first step of…

Q: Diseases which are caused by recessive variants in loci located on the X chromosome affect females…

A: ( Comment: As per the guidelines,we are allowed to answer one question at a time, so repost second…

Q: they argued that promoter switching may be correlated with cancer development and progression…

A: A DNA (deoxyribonucleic acid) sequence where the protein binds and initiates the transcription of…

Q: Which transcription systems that require TBP?

A: Hello. Since your question has multiple parts, we will solve the first question for you. If you want…

Q: What is the main source of energy for ATP replenishment for Cellular Respiration?

A: Introduction ATP or adenosine triphosphate is known as energy currency of cell.  All living…

Q: Given the following scenario, indicate if this will ‘promote’ or ‘prevent’ cancer development: An…

A: Bcl-2, or B-cell lymphoma 2, is a protein that plays a crucial role in regulating apoptosis…

Q: Define the Genomic Instability in cancer cells ? What is leads to ?

A: Genes are the elements that holds responsible for various vital functions in the body. Genes are…

Q: Mutations in genes encoding chromatin-remodeling complexes have been identified in high frequencies…

A: A mutation is a change that occurs in the deoxyribonucleic acid (DNA)when it is damaged or changed…

Q: Activation of p53 during cellular stress will generally Select one: o a. Increase transcription of…

A: P553 is a tumor suppressor gene.

Q: Explain how telomerase expression contributes to theimmortality of cancer cells

A: The tumor cells are said to be immortal due to the expression if telomerase enzyme. The telomerase…

Q: Describe the theory of heterochromatinization and what this theory predicts about global gene…

A: Introduction :- Heterochromatinization is the process by which portions of the genome become…

Q: what category of cancer-related genes is it possible to find inherited variants that are associated…

A: Answer is option 3.

Q: David Seligson and his colleagues examined levels of histone proteinmodification in prostate tumors…

A: The histone protein modification refers to the post translational modification of histones by…

Q: iRNAs are used to “knockdown” gene expression in research. Imagine you are a scientist who hopes to…

A: siRNA: si RNA stands for silencing or short interefing RNA is a double-stranded noncoding RNA that…

Q: Briefly describe three ways that ATP-dependent chromatin-remodeling complexes may change chromatin…

A: In past few years, for the identification and characterization of the ATP-dependent…

Q: Part III – The Second Hit Questions A second hit might occur through epigenetic alterations. In the…

A: The RB1 gene has been linked to retinoblastoma disease. Retinoblastoma is one of the types of cancer…

Q: The yeast cohesin subunit Scc1, which is essen-tial for sister-chromatid cohesion, can be…

A: The foundation of sister chromatid cohesion is the cycle by which chromatin-related cohesin protein…

Q: Explain in detail the meaning of gene fusion. How is this process related to prostate cancer…

A: A gene is referred to as the smallest structural and functional unit of heredity. They are made up…

Q: Explain

A: The process by which information encoded in a gene is used to control the assembly of a protein…

Q: Twist transcription factors (TF) play key roles in embryonic development and are largely…

A: Twist transcription factors (TF) play essential roles in embryonic development but are typically…

Q: You are studying cancer progression in mice. Your results show the following pathway in which two…

A: From the given data the observations made are: The experiment is conducted in a nutrient-enriched…

Q: Cancer can be defined as an abnormal proliferation of cells that defy the normal regulatory controls…

A: It has been proven that epigenetic abnormalities are one of the hallmarks of cancer.…

Q: The MET oncogene is a growth factor receptor that is altered in many forms of cancer including lung…

A: Cancer is a fatal disease that has both physical and mental consequences for a person. Cancer can…

Q: Explain the chromatin remodeling complexes ?

A: In eukaryotes, the DNA is firmly twisted and tightly coiled into a complex called Chromatin. This…

Q: DNA methylation is considered an epigenetic phenomenon because the pattern of methylation can be…

A: Epigenetics is considered as a study of certain gene expressions, which is heritable.

Q: True/False: When first discovered, investigators found it surprising that some single-gene defects…

A: Immunodeficiencies happen when at least one segments of the safe framework is faulty. The most…

Q: Protein P, normally stimulates apoptosis or cell death when activated. Consider a cell with a…

A: The construction of this question gives us an  information about the nature of protein P, P when…

Q: CYCLINs are regulatory proteins active for only portions of the cell cycle.  Their transcription is…

A: Cells are the fundamental units of all living organisms. Cells form different tissues in organisms…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: Cancer often results from a multistage process involving an initiating event (mediated by a viral…

A: Phorbol esters are a group of chemicals that are found in many plants. They are the ester…

Q: Chromosomal translocation can result in cells expressing a fusion protein with uncontrolled receptor…

A: The correct answer is Tel/PDGFR

Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…

A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…

Q: Retinoblastoma is an extremely rare cancer of the retina in the eye. The disease mainly affects…

A: The investigation into retinoblastoma, a uncommon eye cancer fundamentally influencing children,…