An old genetic observation is that a normally active gene will be silenced if it is moved by transposition or crossing over from an uncondensed (euchromatic) region to a heavily condensed (heterochromatic) region of a chromosome. Assume the euchromatic chromatin containing the active gene is surrounded by heterochromatic chromatin immediately after insertion. Please explain in terms of the control of histone modification why the normally active gene is silenced when it becomes surrounded by condensed regions. (Do not explain how histone modification causes chromatin condensation.)
An old genetic observation is that a normally active gene will be silenced if it is moved by transposition or crossing over from an uncondensed (euchromatic) region to a heavily condensed (heterochromatic) region of a chromosome. Assume the euchromatic chromatin containing the active gene is surrounded by heterochromatic chromatin immediately after insertion. Please explain in terms of the control of histone modification why the normally active gene is silenced when it becomes surrounded by condensed regions. (Do not explain how histone modification causes chromatin condensation.)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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An old genetic observation is that a normally active gene will be silenced if it is moved by transposition or crossing over from an uncondensed (euchromatic) region to a heavily condensed (heterochromatic) region of a chromosome. Assume the euchromatic chromatin containing the active gene is surrounded by heterochromatic chromatin immediately after insertion. Please explain in terms of the control of histone modification why the normally active gene is silenced when it becomes surrounded by condensed regions. (Do not explain how histone modification causes chromatin condensation.)
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