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Gene sites sensitive to mutation DNA Components of protein active site Promoter Intron 3' Wild type Exon Exon m1: null m2: null m3: null m4: leaky m5: silent m6: null m2 Active site FIGURE 2-13 Mutations in the parts of a gene encoding enzyme active sites lead to enzymes that do not function (null mutations). Mutations elsewhere in the gene may have no effect on enzyme function (silent mutations). Promoters are sites important in transition initiation. Protein m4 m5 m3 = mutant site

Gene sites sensitive to mutation DNA Components of protein active site Promoter Intron 3' Wild type Exon Exon m1: null m2: null m3: null m4: leaky m5: silent m6: null m2 Active site FIGURE 2-13 Mutations in the parts of a gene encoding enzyme active sites lead to enzymes that do not function (null mutations). Mutations elsewhere in the gene may have no effect on enzyme function (silent mutations). Promoters are sites important in transition initiation. Protein m4 m5 m3 = mutant site

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Considering Figure 2-13, if you had a homozygous double mutant m3/m3 m5/m5, would you expect it to be mutant in phenotype? (Note: This line would have two mutant sites in the same coding sequence.)

Gene sites sensitive to mutation DNA Components of protein active site Promoter Intron 3' Wild type Exon Exon m1: null m2: null m3: null m4: leaky m5: silent m6: null m2 Active site FIGURE 2-13 Mutations in the parts of a gene encoding enzyme active sites lead to enzymes that do not function (null mutations). Mutations elsewhere in the gene may have no effect on enzyme function (silent mutations). Promoters are sites important in transition initiation. Protein m4 m5 m3 = mutant site
Transcribed Image Text:Gene sites sensitive to mutation DNA Components of protein active site Promoter Intron 3' Wild type Exon Exon m1: null m2: null m3: null m4: leaky m5: silent m6: null m2 Active site FIGURE 2-13 Mutations in the parts of a gene encoding enzyme active sites lead to enzymes that do not function (null mutations). Mutations elsewhere in the gene may have no effect on enzyme function (silent mutations). Promoters are sites important in transition initiation. Protein m4 m5 m3 = mutant site
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