Coding sequence -Core promoter -Gene B Core promoter for gene A is moved next to regulatory sequence of депe B Regulatory sequence Inversion Coding sequence Gene A Core promoter (a) Postion effect due to regulatory sequences Active gene Gene Is now Inactive. Translocation Heterochromatic chromosome Translocated heterochromatic chromosome (more compacted) Euchromatic chromosome Shortened euchromatic chromosome (b) Position effect due to translocation to a heterochromatic chromosome FIGURE 19.2 Causes of position effects. (a) A chromosomal inversion has repositioned the core promoter of gene A next to the regulatory sequences for gene B. Because regulatory sequences are often bidirectional, the regulatory sequences for gene B may regulate the transcription of gene A. (b) A translocation has moved a gene from a cuchromatic to a heterochromatic chromosome. This type of position effect inhibits the ex pression of the relocated gene.

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