There are dozens of common variations of the c-myc gene, which are associated with different types of cancer. Here are 3 variations of part of a sequence of the c-myc gene, located between nucleotides 180 and 201. The original sequence is given to you, as well as the sequences of 3 variations. The mutated nucleotide of each variation is annotated in gray. Use this information (picture) to answer the next two (2) questions  1. Which of the c-myc variations is least likely to cause a change in c-myc function? 2. Which variation of c-myc produces a nonsense mutation?

Q: Genes with highly similar sequence are often located adjacent one another in the genome. Gene…

A: Linked genes are genes that are tightly placed on the same chromosome and tend to inherit together.…

Q: Genes with highly similar sequence are often located adjacent one another in the genome. Gene…

A: Gene mutations are changes in single DNA bases, or small intragenic deletions and rearrangements. It…

Q: Which of these epigenetic changes could lead to reduced transcriptlon gene? Please make sure to…

A: Epigenetics is the study of changes in organisms produced by changes in gene expression rather than…

Q: Trichothiodystrophy is a human inherited disorder characterized by premature aging, including…

A: Trichothiodystrophy is a rare, autosomal recessive disease which is characterized by brittle sulfur…

Q: 5. Assume that you are trying to do a gel mobility shift experiment using a normal set of Trp genes.…

A: The gel mobility shift assay is a biochemistry technique used to detect protein complexes with DNA.…

Q: A 210-bp sequence within the CFTR gene on human chromosome 7 is shown below. The three bold…

A: A primer is a short DNA sequence that serves as a starting point for DNA synthesis in a polymerase…

Q: Briefly discuss why mutant allele 1 fails to produce functional protein. Note that this mutation has…

A: A gene is a DNA-based functional heredity unit that delivers instructions for the production of RNA…

Q: The chromosomal sequences of two mutant alleles of gene A from patients with the zero subtype…

A: DNA is the genetic material. An alteration in the DNA sequence of an organism by the substitution or…

Q: Cystic Fibrosis is caused by a mutation in the CFTR gene, and an ideal form of treatment would be to…

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Q: In McCune-Albright syndrome, fibrous connective tissue replaces bone, tan patches (café-au-lait…

A: A mutation is considered a change in the DNA sequence, which can be either an addition or deletion…

Q: Some antibiotics, such as rifampin, interfere with the function of RNA polymerase. What biological…

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Q: What is the underlying genetic defect that causes xeroderma pigmentosum?How can the symptoms of this…

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Q: Concentration (%) A researcher is studying environmental conditions that cause the expression of…

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Q: DNA methylation is considered an epigenetic phenomenon because the pattern of methylation can be…

A: Epigenetics is considered as a study of certain gene expressions, which is heritable.

Q: What are the details of the epigenetic processes involved in gene regulation of Histone…

A: Epigenetic processes assume significant parts in quality guideline by changing histones and DNA,…

Q: Gene duplication

A: Gene Duplications arise from an event termed unequal crossing-over that occurs during meiosis…

Q: How many of the mutations listed below would lead to excessive cell growth when the cell was either…

A: Excessive growth occurs when a cell continuously divides and when there is no cell cycle arrest. Myc…

Q: THE MOLECULAR GENETICS OF CYSTIC FIBROSIS The following is the base sequence of DNA that codes for…

A: According to our guideline we can answer only first 3 subparts of a question. So, upload rest of the…

Q: In Figure 12-4, certain mutations decrease the relativetranscription rate of the β-globin gene.…

A: A promoter is the region of DNA where transcription is initiated. It provides a site for binding of…

Q: If I'm understanding your explanation correctly, do you mean that option D "At the 3’ end of the…

A:

Q: Would a gain of function mutaion that occurs in the first exon of a gene with twelve exons more…

A: Gain-of-function type of mutation is a mutation in which the altered gene product possesses a new…

Q: During construction of a knockout mouse, a targeting vector is introduced into mouse embryonic…

A: Gene targeting is the technique of changing a specific sequence or gene at its location in a genome…

Q: Although most cases of cystic fibrosis are inherited in an autosomal recessive manner, it is…

A: Inheritance is the process of transmitting the traits from parent to offspring. Traits of an…

Q: The Figueroa family has a genetically inherited trait called ocular albinism—lack of pigment in the…

A: In the pedigree, both Becky is the carrier of the disease gene while ben is normal as in…

Q: Lysine 4 of histone H3 (H3K4) is methylated in thenucleosomes of many transcriptionally active…

A: The nuclear genomes of eukaryotes are composed of histones and nonhistone proteins. Histone proteins…

Q: You have created three different mutations in the histoneH1 protein (HISmut1, HISmut2, HISmut3), and…

A: Histone 1 is a type of protein involved in chromatin remodelling. It is a part of histone protein…

Q: DNA methylation is considered an epigenetic phenomenon because the pattern of methylation can be…

A: Epigenetics refers to the phenomenon where traits can be inherited through reverdible changes in…

Q: Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which…

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Q: There is a situation in which a gene has five exons. Please draw four possible mature products of…

A: Alternative splicing is a biological process that involves the joining of exons from the same gene…

Q: The genomes of most multicellular eukaryotes encode~25,000 genes, yet their proteomes contain over…

A: Genes are the stretch of the DNA that codes for the polypeptide chain during the process of gene…

Q: How might a point mutation in DNA affect the phenotype. How the genome is expressed in the organism?…

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Q: The number of protein-encoding genes in a prokaryotic cell equals the number of proteins that can be…

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Q: In Figure 6-1,a. what do the yellow stars represent?b. explain in your own words why the…

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Q: You are working in the lab with two known carcinogens found in cigarette smoke: Benzo(a)pyren (BaP)…

A: Carcinogens are substances or agents that have the ability to cause cancer by altering or damaging…

Q: The abundance of three mRNA transcripts, transcripts A, B, and C, was measured by real-time PCR. The…

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Q: Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease caused by mutations in…

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.