Tay-Sachs disease (TSD) is a fatal genetic disorder, that results in progressive destruction of the nervous system. Tay-Sachs is caused by a mutation in the gene that codes for an enzyme called hexosaminidase-A (Hex-A). Hex A CDNA from normal and a Tay-Sachs individual was sequenced using the same primer. This is the coding strand and starts in-frame at amino acid position #78. Results are shown below. Read the darkest band in each row. Normal Tay-Sachs (-) ATG C ATG C (+) a. Write each coding strand DNA sequence, normal and Tay-Sachs 5' to 3' b. Write the amino acid sequence that will be translated from each sequence, normal and Tay-Sachs C. Describe the type of mutation? Predict the effect of this mutation on the He> A protein.

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A:

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Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.