The genetic alteration responsible for sickle-cell anemia in humans involves: a transition mutation from A to G, substituting glutamic acid for valine in a-globin a transversion mutation from T to A, substituting valine for glutamic acid in b-globin a transition mutation from T to C, substituting valine for glutamic acid in b-globin a transversion mutation from G to C, substituting glutamic acid for valine in a-globin a frameshift mutation of one ATC codon, removing glutamic acid from b-globin

Q: When human hemoglobin undergoes a mutation, the mutant protein usually does not replace all of the…

A: The cytosol of red blood cells contains the oxygen-carrying globular protein hemoglobin, which is…

Q: An experiment was performed in mice.  Wild-type bone marrow is used to reconstitute lethally…

A: The immune system is the body’s defense mechanism against infections and invading pathogens and is…

Q: 1. a)What would happen if the aminoacyl tRNA synthetase responsible for charging alanine tRNAs also…

A: The polymerization of amino acids according to the codons on mRNA to form proteins is known as…

Q: For each of the E. coli strains containing the lacoperon alleles listed, indicate whether the strain…

A: The lac operon is a type of inducible operon, which uses lactose as the source of energy. It gets…

Q: Sickle cell anemia patients suffer from a distorted red blood cell shape and an anemic condition as…

A: d. In sickle cell anemia patients, 100% of the hemoglobin assembled contains the mutant β globin,…

Q: population in Africa is mozygous individuals carrying the Val-6 mutation die from sickle cel emia…

A: Sickle Cell anaemia is a genetic disease that results from a point mutation that results in the…

Q: Draw the SMN2 pre-mRNA (SMN2 has 10 exons and 9 introns), indicate the 5’ and 3’ SS location. [2pts]

A: Spinal muscular atrophy (SMA), which results from the deficiency of articulation of the endurance of…

Q: Hemoglobin, a protein found in red blood cells, carries oxygen. Abnormal hemoglobin cannot carry as…

A: Part A:Messenger RNA sequences produced from the normal and abnormal DNA sequences:Normal DNA…

Q: The synthesis of flower pigments is known to be dependent on enzymatically controlled biosynthetic…

A: A Dihybrid cross is a cross between two different alleles that control two different traits. The…

Q: One of the causes of morbidity for the Zika Virus is Guillain-Barré Syndrome, an immune attack of…

A: Zika virus has family - flaviviridae.  This virus spreds with the help of aedes mosquitoes. They…

Q: Before this experiment, Dr Merrick didn’t know whether the OBP that he cloned was a type of…

A: Proteins can be monomeric or oligomeric. Monomeric proteins have a single subunit (single…

Q: MSH2 is a gene commonly associated with HNPCC (Hereditary nonpolyposis colorectal cancer). This gene…

A: Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an inherited…

Q: ckle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal…

A:

Q: Proteins found in the blood respond to blood vessel damage by clumping together forming a clot that…

A: Answer : b) Produce and store the clotting protein in an inactive form. When the protein is needed,…

Q: Explain what is c-myc translocation and why it results in overexpression of c-myc. What is the role…

A: Epstein-Barr virus or EBV is one of the most common viruses found in the human body. They pass from…

Q: His-64 is an amino acid in myoglobin's herne-binding pocket. It is called the "distal histidine." A…

A: Myoglobin is a oxygen carrying protein similar to hemoglobin, present in muscle tissues that is…

Q: V/D/J recombination frequently yields a gene whose mRNA cannot be successfully translated into an…

A: Somatic recombination is the process for generating antibody and T-cell diversity in mammalian…

Q: Meta analysis C9orf72 Known Novel • 20 15 10 SARM1UNC13A МОВР GPX3-TNIP1 -LOC101927815- SCFD1- 5 CO…

A: ALS (Amyotrophic Lateral Sclerosis) is a group of rare neurological disease. It involves  the motor…

Q: For the mutations described below, categorize them in each of the following ways: [transition,…

A: Understanding the nature of mutations is crucial in comprehending their effects on organisms and…

Q: A mutation creates a dominant negative allele of a particular gene. The gene encodes a protein that…

A: * A monomer is an single subunit and a trimer consists of three monomers bound together with bonds.…

Q: How many of the mutations listed below would lead to excessive cell growth when the cell was either…

A: Excessive growth occurs when a cell continuously divides and when there is no cell cycle arrest. Myc…

Q: One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is…

A: Hypokalemic periodic paralysis is a condition characterized by intermittent episodes of muscle…

Q: The phenotype of a heterozygous mouse (Aa) is agouti.  The agouti banding pattern is due to altered…

A: * Homozygous dominant and Heterozygous will produce agouti that is AA or Aa respectively  and the…

Q: Beadle and Tatum removed arginine and other substances from the nutrient medium of the mutated…

A: Beadle and Tatum experimentally proved the "one gene one enzyme" hypothesis. They took wild-type…

Q: B-thalassemia is a hereditary blood disorder that leads to the formation of an abnormal hemoglobin…

A: Answer is  option A.

Q: The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal…

A: A person with agammaglobulinemia has extremely low levels of the immune system's defense proteins,…

Q: In the absence of tryptophan and the trpD structural gene contains a frameshift insertion mutation,…

A:

Q: hemoglobin with different properties. Which of the following contributes to the varying 02 binding…

A: Hemoglobin is an iron containing protwun. The iron portion of the hemoglobin is called the heme and…

Q: Fetal hemoglobin comprises of αγ sub-units. It has been found that the γ-chain contains serine at…

A: Introduction:- Fetal hemoglobin (HbF) is a prominent type of hemoglobin that is present in the fetus…

Q: Recipient Recipient leu- phe+ his met+ tyr+ leu- phe+ his+ met- tyr+ leu- phe+ his+ met+ tyr- leu-…

A: Bacteria commonly use the three horizontal gene transfer methods of transformation, transduction,…

Q: here is a benign congenital condition called Hereditary Persistence of Fetal Hemoglobin (HPFH) in…

A: Hereditary Persistence of Fetal Hemoglobin is the condition when there is still fetal hemoglobin…

Q: What is the key component(s) of usher syndrome. A) The Effect of mutation and Hot-spots of mutation?…

A: Usher syndrome is a hereditary autosomal disorder passed down through the generations from parent to…

Q: Mutations within the genes for ARSs, are known to be cause certain human maladies, such as the…

A: ARS is an amino-acyl tRNA synthetase that catalyzes the addition of amino acid to the acceptor stem…

Hematology

Hematology is the branch of biology. Hematology is the medical field that deals with the treatment of blood disorders and cancers, such as hemophilia, leukemia, lymphoma, and sickle-cell anemia. Hematologists and hematopathologists are medical professionals who specialize in illnesses of the blood and its components.