[GAINI- is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure. Mutations in GAIN1 have been linked to hypertrophic cardiomyopathy, a disease in which the heart muscle becomes thick- or hypertrophied.] (ii) A cardiovascular scientist wishes to study the function of cardiomyocytes from some of the patients who possess interesting mutations in GAIN1 (a made-up protein) but is unable to isolate cells from these individuals-who are unwilling to let the scientist perform surgery for a cardiac biopsy-. The scientist decides to take skin fibroblasts from these individuals and "reprogram" them into cardiomyocytes for use in his studies. -Explain two ways that the scientist could pursue to do this? -How could the scientist test that it worked? -Name one laboratory technique that the scientist could use to test this.
[GAINI- is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure. Mutations in GAIN1 have been linked to hypertrophic cardiomyopathy, a disease in which the heart muscle becomes thick- or hypertrophied.] (ii) A cardiovascular scientist wishes to study the function of cardiomyocytes from some of the patients who possess interesting mutations in GAIN1 (a made-up protein) but is unable to isolate cells from these individuals-who are unwilling to let the scientist perform surgery for a cardiac biopsy-. The scientist decides to take skin fibroblasts from these individuals and "reprogram" them into cardiomyocytes for use in his studies. -Explain two ways that the scientist could pursue to do this? -How could the scientist test that it worked? -Name one laboratory technique that the scientist could use to test this.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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![[GAIN1 – is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure.
Mutations in GAINI have been linked to hypertrophic cardiomyopathy, a discase in which the heart
muscle becomes thick - or hypertrophied.]
(ii) A cardiovascular scientist wishes to study the function of cardiomyocytes from some of the
patients who possess interesting mutations in GAIN1 (a made-up protein) but is unable to
isolate cells from these individuals -who are unwilling to let the scientist perform surgery for a
cardiac biopsy-. The scientist decides to take skin fibroblasts from these individuals and
"reprogram" them into cardiomyocytes for use in his studies.
-Explain two ways that the scientist could pursue to do this?
-How could the scientist test that it worked?
-Name one laboratory technique that the scientist could use to test this.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F880b8c73-cbc7-4f0a-930b-6c34e16b69d8%2F7bfcf17a-75e6-4ef0-bbf2-e07384476575%2F2vse55_processed.jpeg&w=3840&q=75)
Transcribed Image Text:[GAIN1 – is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure.
Mutations in GAINI have been linked to hypertrophic cardiomyopathy, a discase in which the heart
muscle becomes thick - or hypertrophied.]
(ii) A cardiovascular scientist wishes to study the function of cardiomyocytes from some of the
patients who possess interesting mutations in GAIN1 (a made-up protein) but is unable to
isolate cells from these individuals -who are unwilling to let the scientist perform surgery for a
cardiac biopsy-. The scientist decides to take skin fibroblasts from these individuals and
"reprogram" them into cardiomyocytes for use in his studies.
-Explain two ways that the scientist could pursue to do this?
-How could the scientist test that it worked?
-Name one laboratory technique that the scientist could use to test this.
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