Answered: An experiment was performed in mice.…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

An experiment was performed in mice. Wild-type bone marrow is used to reconstitute lethally irradiated Cr2^-/- mice (wt®Cr2-/-), or vice versa (Cr2-/-®wt). As controls, Cr2^-/- bone marrow is used to reconstitute Cr2-/- recipients (Cr2-/-®Cr2-/-), and wild-type bone marrow used to reconstitute wild-type recipients (wt®wt). These mice are then inoculated with the HSV-rd virus at 10⁶ PFU, once at day 0 and then a second time at day 28, and the anti-HSV IgG responses are measured every 7 days, as shown in figure below.

a) From the data shown above, on which cell type is the expression of the complement receptor most important for humoral immunity?

b) For each of the cell types expressing the complement receptor encoded by Cr2, what is the explanation for their importance in humoral immunity to HSV inoculation?

103 -
102 -
10'
10° -
1 2 3 4 5 6 7
Weeks
post-
vaccination
Primary
immunization
Secondary
immunization
Wild-type
Cr2 → wt
wt - Cr2+
Cr2-→ Cr2--
Anti-HSV IgG Ab (µg/ml)

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