Variable addition and subtraction of nucleotides at the junctions between gene segments contributes to the diversity of [Qi] the third hypervariable region. The addition and subtraction of nucleotides at the junctions between V, D, and J gene segments creates antibody proteins with wide variations in the numbers of amino acids in their CDR3 regions. This variability in CDR3 length is important as:Overall variability in CDR3 sequence is needed to create a sufficiently diverse antibody repertoire.The CDR3 region is more important in binding antigen than the CDR1 and CDR2 regions are.Some light chains bind better to heavy chains with longer CDR3 region sequences.Longer CDR3 sequences generally create antibodies with higher affinity for the antigen.Some antibodies bind relatively flat surfaces and others bind deep clefts in the antigen.

Our immune system plays a major role in protecting our bodies from infections, pathogens, and other…

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Variable addition and subtraction of nucleotides at the junctions between gene segments contributes to the diversity of [Qi] the third hypervariable region. The addition and subtraction of nucleotides at the junctions between V, D, and J gene segments creates antibody proteins with wide variations in the numbers of amino acids in their CDR3 regions. This variability in CDR3 length is important as:

Overall variability in CDR3 sequence is needed to create a sufficiently diverse antibody repertoire.
The CDR3 region is more important in binding antigen than the CDR1 and CDR2 regions are.
Some light chains bind better to heavy chains with longer CDR3 region sequences.
Longer CDR3 sequences generally create antibodies with higher affinity for the antigen.
Some antibodies bind relatively flat surfaces and others bind deep clefts in the antigen.

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