gamma:delta T-cell receptors are also generated by gene rearrangement. Some T cells express gamma:delta T-cell receptors rather than alpha:beta T-cell receptors. The organization of the a locus and the d locus helps to ensure that each T cell cannot express both types of T-cell receptors. The mechanism involved is that:The rearrangement of a T-cell receptor a gene deletes the d locus on that allele.The rearrangement of a T-cell receptor d gene deletes the a locus on that allele.The RAG recombinase enzymes are down-regulated immediately after the first T-cell receptor genes rearrange.The a:b T-cell receptor signals the T cell to delete the d locus.The g:d T-cell receptor signals the T cell to delete the a locus.

Introduction: The gamma-delta T cells are the ones that display a typical T cell receptor on their…

Answered: gamma:delta T-cell receptors are also…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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gamma:delta T-cell receptors are also generated by gene rearrangement. Some T cells express gamma:delta T-cell receptors rather than alpha:beta T-cell receptors. The organization of the a locus and the d locus helps to ensure that each T cell cannot express both types of T-cell receptors. The mechanism involved is that:

The rearrangement of a T-cell receptor a gene deletes the d locus on that allele.
The rearrangement of a T-cell receptor d gene deletes the a locus on that allele.
The RAG recombinase enzymes are down-regulated immediately after the first T-cell receptor genes rearrange.
The a:b T-cell receptor signals the T cell to delete the d locus.
The g:d T-cell receptor signals the T cell to delete the a locus.

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