Hyper-IgE syndrome, also known as Job’s syndrome, is an immunodeficiency disease resulting from the lack of function of a single gene (gene ‘X’). Patients with this disease are highly susceptible to infections with extracellular bacteria and fungi, most frequently including Staphylococcus aureus infections and Candida albicans infections in the skin. Analysis of the various immune cell compartments indicates that these patients have normal numbers of each cell lineage (i.e., CD4 and CD8 T cells, B cells, monocytes, dendritic cells, NK cells, granulocytes, etc.), and normal levels of IgG, IgA, and IgM antibodies, but higher than normal levels of IgE.  Given this information, name a likely component of the immune response that could be impaired in these patients.

Q: The current estimate is that mammalian B cells are capable of producing 1,010 different…

A: Immunoglobulins are composed of four polypeptide chains out of which two are heavy chains and two…

Q: Most of the enzymes involved in immunoglobulin gene rearrangement are ubiquitously expressed in all…

A: Introduction: The enzymes RAG 1 & RAG 2 cut and rearranges DNA to produce different types of…

Q: how  Misguided translocations can help cause Burkitt lymphoma?

A: Burkitt lymphoma is a rare cancer of the B-lymphocytes. It is a solid tumor that mostly affects…

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A: Antigens activate your immune response, causing it to unleash an antibody response. Antibodies…

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Q: Why is the precise timing of recombination events critical during B and T cell development?.

A: B and T cell development is the complex biological process through which precursor cells mature into…

Q: Describe the major chromosomal translocation that results in deregulated oncogenic signaling and…

A: Translocation is a process in which a part of the chromosomes is separated and joints with the other…

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A: Tuberculosis is caused by Mycobacterium tuberculosis.

Q: (a) Identify both the cellular component and the location of the component that is responsible for…

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Q: Mike, an unvaccinated university student traveled to Western Europe, where he contracted mumps…

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Q: Three major cell types, dendritic cells, macrophages, and B cells, present peptides bound to MHC…

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Q: Genetic factors contribute to the development of IgE-mediated allergic disease.  Genetic studies…

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Q: in several populations, SNPs were genotyped for the major histocompatibility class (MHC) II region…

A: MHC II stands for Major Histocompatibility Complex class II. It is a group of genes that play a…

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A: Adaptive immunity is made up of two main components: T cells and B cells. An immune system that…

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Q: The figure below illustrates the development of white blood cells from stem cells in the bone marrow…

A: White blood cells, or leukocytes, are vital components of the human immune system. They originate…

Q: high

A: In sensitized individuals, on the surface of tissue cells (basophils and mast cells) the IgE…

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A: Cytokines are immunological molecules present in biological systems that are important for cell…

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Q: Suppose that a particular species of vertebrate animal has immunoglobulin heavy-chain genes that…

A: ANSWER;-

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Q: Individuals who express HLA-B27 are 90 times more likely to develop the autoimmune disorder…

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Q: A 55-year-old male was diagnosed with rheumatoid arthritis (RA) after experiencing complications…

A: Rheumatoid arthritis is an autoimmune disease. An autoimmune disease refers to when the body's…

Q: each complementation group in the blanks provided below. (Some of the blanks may remain empty.) Cd e…

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Q: Can a mature B Cell produce an epitope-specific antibody first and then switch to make an antibody…

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Q: In a mixed lymphocyte reaction, T cells from individual A make a robust response to…

A: Immunity is an organism's ability to defend against a particular disease or through the activation…

Immunology

Immunology is the division of science involved with the immune reactions occurring in living organisms. The organisms are accustomed to evolving internal defense mechanisms to evade the invasion of microbial pathogens. Diverse cells are connected with stimulating the immune responses, which produce inhospitable conditions to the microbes prompting their lysis and thus inhibits the multiplication of the pathogens. The immune system can distinguish the pathogens through the aid of cellular intercommunication and launch responses to destroy them.