The adaptive immune system uses multiple strategies to generate diversity in our ability to mount responses to a wide array of infectious microorganisms. These strategies include the generation of diverse repertoires of B-cell and T-cell antigen receptors, as well as polymorphism of MHC genes. The polymorphism of MHC genes differs from the diversity of lymphocyte antigen receptors in that:It involves DNA rearrangements at multiple gene segments in the MHC locus.It requires different enzymes than the RAG1/RAG2 recombinase required for antigen receptor rearrangements.It results in a diverse repertoire of clonally distributed receptors on dendritic cells, rather than on lymphocytes.It creates diversity between individuals in the population rather than within a single individual.It does not contribute to the transplant rejection responses that occur after organ transplantation between unrelated individuals.

Adaptive immunity is made up of two main components: T cells and B cells. An immune system that…

Answered: The adaptive immune system uses…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The adaptive immune system uses multiple strategies to generate diversity in our ability to mount responses to a wide array of infectious microorganisms. These strategies include the generation of diverse repertoires of B-cell and T-cell antigen receptors, as well as polymorphism of MHC genes. The polymorphism of MHC genes differs from the diversity of lymphocyte antigen receptors in that:

It involves DNA rearrangements at multiple gene segments in the MHC locus.
It requires different enzymes than the RAG1/RAG2 recombinase required for antigen receptor rearrangements.
It results in a diverse repertoire of clonally distributed receptors on dendritic cells, rather than on lymphocytes.
It creates diversity between individuals in the population rather than within a single individual.
It does not contribute to the transplant rejection responses that occur after organ transplantation between unrelated individuals.

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