Alefacept is a fusion protein that contains the CD2-binding domain of LFA3 fused to human IgG1, and it is used to block CD2 function on human T cells. In addition, following in vivo administration, alefacept was also shown to deplete T cells of the effector or memory subsets that express high levels of CD2. Surprisingly, clinical trials data indicated that patients on alefacept still retained responses to vaccination. For example, one set of data showed that patients on alefacept made similar responses as the control group to a vaccine designed to protect against pneumococcal disease, which is composed entirely of bacterial polysaccharide antigens (pneumococcal polysaccharide vaccine; PPV). This normal response to PPV by patients on alefacept is not surprising because: Alefacept is not very effective at blocking T cell responses. CD2 is not required for all T cell responses to vaccination. Alefacept does not deplete all effector or memory T cells, just a subset. T cells are involved in responses to polysaccharide antigens. The PPV was eliciting a recall response in previously exposed individuals.

Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
Problem 1SRQ
icon
Related questions
Question

Alefacept is a fusion protein that contains the CD2-binding domain of LFA3 fused to human IgG1, and it is used to block CD2 function on human T cells. In addition, following in vivo administration, alefacept was also shown to deplete T cells of the effector or memory subsets that express high levels of CD2. Surprisingly, clinical trials data indicated that patients on alefacept still retained responses to vaccination. For example, one set of data showed that patients on alefacept made similar responses as the control group to a vaccine designed to protect against pneumococcal disease, which is composed entirely of bacterial polysaccharide antigens (pneumococcal polysaccharide vaccine; PPV). This normal response to PPV by patients on alefacept is not surprising because:

  1. Alefacept is not very effective at blocking T cell responses.
  2. CD2 is not required for all T cell responses to vaccination.
  3. Alefacept does not deplete all effector or memory T cells, just a subset.
  4. T cells are involved in responses to polysaccharide antigens.
  5. The PPV was eliciting a recall response in previously exposed individuals.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Immune response
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, nursing and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Phlebotomy Essentials
Phlebotomy Essentials
Nursing
ISBN:
9781451194524
Author:
Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:
JONES+BARTLETT PUBLISHERS, INC.
Gould's Pathophysiology for the Health Profession…
Gould's Pathophysiology for the Health Profession…
Nursing
ISBN:
9780323414425
Author:
Robert J Hubert BS
Publisher:
Saunders
Fundamentals Of Nursing
Fundamentals Of Nursing
Nursing
ISBN:
9781496362179
Author:
Taylor, Carol (carol R.), LYNN, Pamela (pamela Barbara), Bartlett, Jennifer L.
Publisher:
Wolters Kluwer,
Fundamentals of Nursing, 9e
Fundamentals of Nursing, 9e
Nursing
ISBN:
9780323327404
Author:
Patricia A. Potter RN MSN PhD FAAN, Anne Griffin Perry RN EdD FAAN, Patricia Stockert RN BSN MS PhD, Amy Hall RN BSN MS PhD CNE
Publisher:
Elsevier Science
Study Guide for Gould's Pathophysiology for the H…
Study Guide for Gould's Pathophysiology for the H…
Nursing
ISBN:
9780323414142
Author:
Hubert BS, Robert J; VanMeter PhD, Karin C.
Publisher:
Saunders
Issues and Ethics in the Helping Professions (Min…
Issues and Ethics in the Helping Professions (Min…
Nursing
ISBN:
9781337406291
Author:
Gerald Corey, Marianne Schneider Corey, Cindy Corey
Publisher:
Cengage Learning