NCR- ILC3 make up one of the most frequent ILC subsets in the human peripheral blood, while NCR+ ILC3 are virtually absent in the circulation during homeostasis. Importantly, the healthy human intestine hosts dominantly NCR+ILC3, which have been shown to be essential in maintaining gut homeostasis. The signature cytokine of NCR+ ILC3 is IL-22. ILC3 in mice sense their environment and control gut defense as part of a glial-ILC3-epithelial cell unit orchestrated by neurotrophic factors. Enteric ILC3 express the neuroregulatory receptor RET. ILC3-autonomous Ret ablation led to decreased innate interleukin-22 (IL-22), impaired epithelial reactivity, dysbiosis and increased susceptibility to bowel inflammation and infection. Does this this complex neuro immune cross talk in the intestine account for the NCR ILC3 cells producing IL-22 while no such associations exist in the circulation where the ILC3 cells are NCR- and produce IL-17? maybe O yes O no

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
icon
Concept explainers
Question
NCR- ILC3 make up one of the most frequent ILC subsets in the human peripheral
blood, while NCR+ ILC3 are virtually absent in the circulation during homeostasis.
Importantly, the healthy human intestine hosts dominantly NCR+ILC3, which have
been shown to be essential in maintaining gut homeostasis. The signature cytokine
of NCR+
ILC3 is IL-22. ILC3 in mice sense their environment and control gut defense as part
of a glial-ILC3-epithelial cell unit orchestrated by neurotrophic factors. Enteric ILC3
express the neuroregulatory receptor RET. ILC3-autonomous Ret ablation led to
decreased innate interleukin-22 (IL-22), impaired epithelial reactivity, dysbiosis and
increased susceptibility to bowel inflammation and infection. Does this this complex
neuro immune cross talk in the intestine account for the NCR ILC3 cells producing
IL-22 while no such associations exist in the circulation where the ILC3 cells are
NCR- and produce IL-17?
maybe
O yes
O no
Transcribed Image Text:NCR- ILC3 make up one of the most frequent ILC subsets in the human peripheral blood, while NCR+ ILC3 are virtually absent in the circulation during homeostasis. Importantly, the healthy human intestine hosts dominantly NCR+ILC3, which have been shown to be essential in maintaining gut homeostasis. The signature cytokine of NCR+ ILC3 is IL-22. ILC3 in mice sense their environment and control gut defense as part of a glial-ILC3-epithelial cell unit orchestrated by neurotrophic factors. Enteric ILC3 express the neuroregulatory receptor RET. ILC3-autonomous Ret ablation led to decreased innate interleukin-22 (IL-22), impaired epithelial reactivity, dysbiosis and increased susceptibility to bowel inflammation and infection. Does this this complex neuro immune cross talk in the intestine account for the NCR ILC3 cells producing IL-22 while no such associations exist in the circulation where the ILC3 cells are NCR- and produce IL-17? maybe O yes O no
Expert Solution
steps

Step by step

Solved in 3 steps

Blurred answer
Knowledge Booster
Organ system
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education