Describe the binding site for superantigens on T cells andAPCs. How does this relate to the activation of a much largerpopulation of T cells than normal upon exposure tosuperantigens?
Describe the binding site for superantigens on T cells andAPCs. How does this relate to the activation of a much largerpopulation of T cells than normal upon exposure tosuperantigens?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Describe the binding site for superantigens on T cells and
APCs. How does this relate to the activation of a much larger
population of T cells than normal upon exposure to
superantigens?
Expert Solution
Step 1
Step 1
Superantigens are microbial protein. The size of superantigens is of 22-29 Daltons in size and are powerful stimulator of the immune cells in an unusual manner produced by bacteria, virus, and mycoplasma. Superantigen has two domain folding- the NH2 terminal beta-barrel that provides a binding region for the MHC-II receptor and the other domain with long COOH (carboxylic acid) alpha terminal barrel that binds Vbeta region of TCR (T-cell receptor).
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