TCR and CD28 signaling together leads to maximal production of IL-2 by the activated T cell. Experiments investigating the mechanism underlying the CD28 co-stimulation-mediated increase in IL-2 production show that T cells stimulated through the TCR plus CD28 have increased levels of IL-2 mRNA compared to cells stimulated through the TCR alone. One important component contributing to increased IL-2 mRNA levels is increased mRNA stability after transcription and splicing. increased glucose metabolism due to increased production of glycolytic enzymes. increased protein synthesis due to increased production of ribosomes. enhanced mRNA transport from the nucleus to the cytoplasm.

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Q: 12445 RD-Hom 4(167-277) A(194-277) A(97-138) A(97-167) 6 A(97-194) N595A 7890 A(619-723) HD 10…

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Q: Based on the data shown in chart, titled IL-2 Response by Macrophages that express TLR-XX would you…

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Q: high

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A: Hypothesis: SIN-47 works by disrupting the interaction between LEK2 and JAK4.

Q: trigger

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Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.