Homework Help is Here – Start Your Trial Now!
Science
Biology
TCRs versus antibodies, the overall domain organization of the TCR is not the same as for an antibody. In the figure below, describe three features that are incorrect illustrations of the alpha:beta TCR.

TCRs versus antibodies, the overall domain organization of the TCR is not the same as for an antibody. In the figure below, describe three features that are incorrect illustrations of the alpha:beta TCR.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question

alpha:beta TCRs are membrane-bound proteins comprised of two polypeptides linked by a disulfide bond. Both polypeptide components of the alpha:beta TCR are members of the immunoglobulin superfamily, and each of their domains share structural similarity with regions of antibody proteins. However, due to the different functions of TCRs versus antibodies, the overall domain organization of the TCR is not the same as for an antibody. In the figure below, describe three features that are incorrect illustrations of the alpha:beta TCR.

### T-Cell Receptor Structure and Function #### Diagram Explanation: The image depicts the structure of a T-cell receptor (TCR), which plays a crucial role in the immune system by recognizing antigens. The TCR is composed of two different protein chains, termed the alpha (α) and beta (β) chains. Each chain consists of several domains: 1. **Variable (V) Domains:** Located at the outermost part of the TCR, these domains are responsible for binding to antigens. They are labeled 'V' in the diagram, with one in yellow (α chain) and one in green (β chain). 2. **Constant (C) Domains:** These domains are situated closer to the cell membrane and are labeled 'C' in the diagram. They provide structural support and stability to the receptor. Both the α chain and β chain have constant domains, depicted in yellow and green, respectively. 3. **Disulfide Bonds:** These bonds, illustrated as lines between the α and β chains, help maintain the structural integrity of the TCR by linking the chains together. Disulfide bonds are crucial for the proper folding and functioning of the receptor. 4. **Antigen-Binding Sites:** The variable domains of the α and β chains come together to form the antigen-binding sites of the TCR. This is where the receptor binds to antigens presented by the Major Histocompatibility Complex (MHC) molecules on the surface of other cells. 5. **Cell Membrane:** The base of the diagram represents the cell membrane into which the TCR is anchored. This positioning allows the receptor to interact with antigens presented on the surface of other cells. The T-cell receptor is essential for the immune response, as it enables T cells to detect and respond to pathogens by recognizing specific antigens. This interaction triggers T-cell activation and subsequent immune responses, including the elimination of infected or cancerous cells. Understanding the structure of the TCR helps in comprehending its function in immune surveillance and its role in diseases and therapies, such as in the development of T-cell-based immunotherapies for cancer.
Transcribed Image Text:### T-Cell Receptor Structure and Function #### Diagram Explanation: The image depicts the structure of a T-cell receptor (TCR), which plays a crucial role in the immune system by recognizing antigens. The TCR is composed of two different protein chains, termed the alpha (α) and beta (β) chains. Each chain consists of several domains: 1. **Variable (V) Domains:** Located at the outermost part of the TCR, these domains are responsible for binding to antigens. They are labeled 'V' in the diagram, with one in yellow (α chain) and one in green (β chain). 2. **Constant (C) Domains:** These domains are situated closer to the cell membrane and are labeled 'C' in the diagram. They provide structural support and stability to the receptor. Both the α chain and β chain have constant domains, depicted in yellow and green, respectively. 3. **Disulfide Bonds:** These bonds, illustrated as lines between the α and β chains, help maintain the structural integrity of the TCR by linking the chains together. Disulfide bonds are crucial for the proper folding and functioning of the receptor. 4. **Antigen-Binding Sites:** The variable domains of the α and β chains come together to form the antigen-binding sites of the TCR. This is where the receptor binds to antigens presented by the Major Histocompatibility Complex (MHC) molecules on the surface of other cells. 5. **Cell Membrane:** The base of the diagram represents the cell membrane into which the TCR is anchored. This positioning allows the receptor to interact with antigens presented on the surface of other cells. The T-cell receptor is essential for the immune response, as it enables T cells to detect and respond to pathogens by recognizing specific antigens. This interaction triggers T-cell activation and subsequent immune responses, including the elimination of infected or cancerous cells. Understanding the structure of the TCR helps in comprehending its function in immune surveillance and its role in diseases and therapies, such as in the development of T-cell-based immunotherapies for cancer.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Immune response
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS