1. SARS-CoV versus SARS-CoV-2 Compare the protein sequence of the SARS-CoV and SARS-CoV-2. Do you think the antibody towards the former will most likely bind to the latter? Explain your answer. Note: the spike protein of the SARS-CoV and SARS-CoV-2 were aligned, and the regions in a black rectangular box as the "critical residues for binding". Fig. 4: Sequence alignment and structural comparison of SARS-COV and SARS-CoV-2 spike proteins. SARS COV spike protein (116-510) FPNITNLCPFGEVENATEFISVYAMERKKISNCVADYSVLYNSTESTFK S SARS-CoV-2 spike protein 3-53 FPNITNLCPFGEVENATRFASVYANRKRISNCVADYSVLYNSASFSTFK SARS COV spike protein (16-S10 6 CYOVSÄTKLNDLCPENVYADSFVVKGDOVROIAPGOTCIADYNYKLPOD 41S SARS CoV2 spike protein (38-5I CYGVSTKLNDLCPINVYADSFVIRGDEVROIAPGOTIADYNYKLPOD 4 SARS COV spike protein (316-510 46 PacVLANTRTDATSTGNYNYYRYAGKLRPFERDISNVIESPOGKs SARS COV pike protein 3-SIN s GCVIANISNNLOSKVOGNYNYYRLERKSNLKPTERDISTEYOAGST7 SARS CoV spe protein 16-51 4P-FPALNCYMPLNDYGFTTC SARS CoV-2 spke protein (138-53 s PcNGVEGENCYEPLOYGrOrNGVGYOPYRVVVLSPELLHAPATV S dPYRVVVLSFELLNAPATV S0 Tay, Matthew Zirui, et al. Nature Reviews Immunology 20.6 (2020): 363-374.
1. SARS-CoV versus SARS-CoV-2 Compare the protein sequence of the SARS-CoV and SARS-CoV-2. Do you think the antibody towards the former will most likely bind to the latter? Explain your answer. Note: the spike protein of the SARS-CoV and SARS-CoV-2 were aligned, and the regions in a black rectangular box as the "critical residues for binding". Fig. 4: Sequence alignment and structural comparison of SARS-COV and SARS-CoV-2 spike proteins. SARS COV spike protein (116-510) FPNITNLCPFGEVENATEFISVYAMERKKISNCVADYSVLYNSTESTFK S SARS-CoV-2 spike protein 3-53 FPNITNLCPFGEVENATRFASVYANRKRISNCVADYSVLYNSASFSTFK SARS COV spike protein (16-S10 6 CYOVSÄTKLNDLCPENVYADSFVVKGDOVROIAPGOTCIADYNYKLPOD 41S SARS CoV2 spike protein (38-5I CYGVSTKLNDLCPINVYADSFVIRGDEVROIAPGOTIADYNYKLPOD 4 SARS COV spike protein (316-510 46 PacVLANTRTDATSTGNYNYYRYAGKLRPFERDISNVIESPOGKs SARS COV pike protein 3-SIN s GCVIANISNNLOSKVOGNYNYYRLERKSNLKPTERDISTEYOAGST7 SARS CoV spe protein 16-51 4P-FPALNCYMPLNDYGFTTC SARS CoV-2 spke protein (138-53 s PcNGVEGENCYEPLOYGrOrNGVGYOPYRVVVLSPELLHAPATV S dPYRVVVLSFELLNAPATV S0 Tay, Matthew Zirui, et al. Nature Reviews Immunology 20.6 (2020): 363-374.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Question
Transcribed Image Text:1. SARS-CoV versus SARS-CoV-2
Compare the protein sequence of the SARS-CoV and SARS-CoV-2. Do you think the antibody
towards the former will most likely bind to the latter? Explain your answer. Note: the spike
protein of the SARS-CoV and SARS-CoV-2 were aligned, and the regions in a black
rectangular box as the "critical residues for binding".
Fig. 4: Sequence alignment and structural comparison of SARS-COV and SARS-CoV-2
spike proteins.
SARS COV spike protein (116-510) FPNITNLCPFGEVENATEFISVYAMERKKISNCVADYSVLYNSTESTFK S
SARS-CoV-2 spike protein 3-53 FPNITNLCPFGEVENATRFASVYANRKRISNCVADYSVLYNSASFSTFK
SARS COV spike protein (16-S10 6 CYOVSÄTKLNDLCPENVYADSFVVKGDOVROIAPGOTCIADYNYKLPOD 41S
SARS CoV2 spike protein (38-5I CYGVSTKLNDLCPINVYADSFVIRGDEVROIAPGOTIADYNYKLPOD 4
SARS COV spike protein (316-510 46 PacVLANTRTDATSTGNYNYYRYAGKLRPFERDISNVIESPOGKs
SARS COV pike protein 3-SIN s GCVIANISNNLOSKVOGNYNYYRLERKSNLKPTERDISTEYOAGST7
SARS CoV spe protein 16-51 4P-FPALNCYMPLNDYGFTTC
SARS CoV-2 spke protein (138-53 s PcNGVEGENCYEPLOYGrOrNGVGYOPYRVVVLSPELLHAPATV S
dPYRVVVLSFELLNAPATV S0
Tay, Matthew Zirui, et al. Nature Reviews Immunology 20.6 (2020): 363-374.
Expert Solution
Step 1
The pandemic of the disease called COVID-19 is caused by the virus called SARS-CoV-2 virus. The name of the virus stands for the severe acute respiratory syndrome coronavirus-2 as this belongs to the coronavirus family and affects the upper respiratory tract infections including in the lungs.
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education