You have in your possession five mouse strains. The mice of each strain lack a specific gene (i.e., they are gene- knockout animals). • Strain A: Mice are unable to generate an & heavy chain. • Strain B: Mice are unable to generate a high-affinity FCERI receptor. • Strain C: Mice are unable to generate a low-affinity FCERII receptor. • Strain D: Mice are deficient in the ability to generate the complement attack complex. ⚫ Strain E: Mice are unable to express CD21. Assign each description to one or more mouse strains to explain how type I and type II hypersensitivity responses differ from wild-type mice. Unable to generate an ε heavy chain. Unable to generate a high-affinity FCεRI receptor. Answer Bank There might be a type I response but it might be abnormal. Unable to generate a low-affinity FcεRII receptor. Deficient in the ability to generate the complement attack complex. Unable to express CD21. There might be a type II response but it might be supressed. There will be a type II response mediated by IgG or IgM. There will be no type II response. There will be no type I response. There will be a type I response mediated by IgE interactions.

You have in your possession five mouse strains. The mice of each strain lack a specific gene (i.e., they are gene- knockout animals). • Strain A: Mice are unable to generate an & heavy chain. • Strain B: Mice are unable to generate a high-affinity FCERI receptor. • Strain C: Mice are unable to generate a low-affinity FCERII receptor. • Strain D: Mice are deficient in the ability to generate the complement attack complex. ⚫ Strain E: Mice are unable to express CD21. Assign each description to one or more mouse strains to explain how type I and type II hypersensitivity responses differ from wild-type mice. Unable to generate an ε heavy chain. Unable to generate a high-affinity FCεRI receptor. Answer Bank There might be a type I response but it might be abnormal. Unable to generate a low-affinity FcεRII receptor. Deficient in the ability to generate the complement attack complex. Unable to express CD21. There might be a type II response but it might be supressed. There will be a type II response mediated by IgG or IgM. There will be no type II response. There will be no type I response. There will be a type I response mediated by IgE interactions.

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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