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A 150₁ 100- Cell-to-cell transmission (Relative, %) U D SARS-CoV SARS-CoV-2 Cell-to-cell transmission (Relative, %) 50- 1501 100- 50- 293T to 293T/ACE2 ns ns 0 0.2 2.0 Mock 293T to 293T/ACE2 ns Ctri Sera Sera: SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 2B04 (µg/mL) 0.2 µg/mL 2B04 #3 era #4 Serai SARS-CoV (PV) SARS-CoV-2 (PV) ns Ctrl Sera #22 B 1501 100 Cell-free infection (Relative, %) E 50- 0 Cell-free infection (Relative, %) 100- SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 0 0.2 2.0 2B04 (µg/mL) ns 2.0 µg/mL 2B04 150 293T/ACE2 ns ns Ctrl Sera Sera #1 293T/ACE2 SARS-CoV (PV) SARS-CoV-2 (PV) Sera #5 Ctri Sera Sera

A 150₁ 100- Cell-to-cell transmission (Relative, %) U D SARS-CoV SARS-CoV-2 Cell-to-cell transmission (Relative, %) 50- 1501 100- 50- 293T to 293T/ACE2 ns ns 0 0.2 2.0 Mock 293T to 293T/ACE2 ns Ctri Sera Sera: SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 2B04 (µg/mL) 0.2 µg/mL 2B04 #3 era #4 Serai SARS-CoV (PV) SARS-CoV-2 (PV) ns Ctrl Sera #22 B 1501 100 Cell-free infection (Relative, %) E 50- 0 Cell-free infection (Relative, %) 100- SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 0 0.2 2.0 2B04 (µg/mL) ns 2.0 µg/mL 2B04 150 293T/ACE2 ns ns Ctrl Sera Sera #1 293T/ACE2 SARS-CoV (PV) SARS-CoV-2 (PV) Sera #5 Ctri Sera Sera

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A 150- 100- Cell-to-cell transmission (Relative, %) SARS-CoV SARS-CoV-2 Cell-to-cell transmission (Relative, %) 1501 100- 50- 293T to 293T/ACE2 ns ns 0 0.2 2.0 Ctri Sera SH Mock 293T to 293T/ACE2 ns era #11 SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 2B04 (µg/mL) 0.2 µg/mL 2B04 SARS-CoV (PV) SARS-CoV-2 (PV) ns #5 Sera Ctri Sera Sera Sera #11 B Cell-free infection (Relative, %) E 150 100- 50- Cell-free infection (Relative, %) 100- 50- ns 0 0.2 2.0 2.0 μg/mL 2B04 150 Ctri Sera 293T/ACE2 ns ns T SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 2B04 (µg/mL) 293T/ACE2 SARS-CoV (PV) SARS-CoV-2 (PV) Sera #5 Ctri Sera #11 Sera Fig. 6. Cell-to-cell transmission of SARS-CoV-2 is refractory to inhibition by neutralizing antibody and COVID-19 convalescent plasma. (A-C) Effects of SARS-CoV-2 monoclonal antibody 2B04 on cell-to-cell transmission, cell-free infection, and cell-cell fusion mediated by SARS-CoV-2 or SARS-CoV-2 spike. The experiments were carried out as described in Fig. 1 C and D, except that 0.2 µg/mL or 2 µg/mL 2B04 were included during the infection period. Rela- tive infections were plotted by setting the values of mock infection without 2804 to 100% for statistical analyses (A and B). The photos of syncytia forma- tion were taken at 18 h after coculture and presented (C). (D and E) Effect of COVID-19 sera on cell-to-cell and cell-free infection of SARS-CoV-2 and SARS-CoV. Experiments were performed as described as above, except five diluted COVID-19 sera were included during the infection period. Effect on cell-to-cell (D) and cell-free (E) infection of SARS-CoV or SARS-CoV-2 were summarized and plotted by setting the values of mock infection control to 100% (n = ~3 to 4). PV, pseudotyped virus. **P<0.01, ***P<0.001. ns, not significant.
Transcribed Image Text:A 150- 100- Cell-to-cell transmission (Relative, %) SARS-CoV SARS-CoV-2 Cell-to-cell transmission (Relative, %) 1501 100- 50- 293T to 293T/ACE2 ns ns 0 0.2 2.0 Ctri Sera SH Mock 293T to 293T/ACE2 ns era #11 SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 2B04 (µg/mL) 0.2 µg/mL 2B04 SARS-CoV (PV) SARS-CoV-2 (PV) ns #5 Sera Ctri Sera Sera Sera #11 B Cell-free infection (Relative, %) E 150 100- 50- Cell-free infection (Relative, %) 100- 50- ns 0 0.2 2.0 2.0 μg/mL 2B04 150 Ctri Sera 293T/ACE2 ns ns T SARS-CoV (PV) SARS-CoV-2 (PV) 0 0.2 2.0 2B04 (µg/mL) 293T/ACE2 SARS-CoV (PV) SARS-CoV-2 (PV) Sera #5 Ctri Sera #11 Sera Fig. 6. Cell-to-cell transmission of SARS-CoV-2 is refractory to inhibition by neutralizing antibody and COVID-19 convalescent plasma. (A-C) Effects of SARS-CoV-2 monoclonal antibody 2B04 on cell-to-cell transmission, cell-free infection, and cell-cell fusion mediated by SARS-CoV-2 or SARS-CoV-2 spike. The experiments were carried out as described in Fig. 1 C and D, except that 0.2 µg/mL or 2 µg/mL 2B04 were included during the infection period. Rela- tive infections were plotted by setting the values of mock infection without 2804 to 100% for statistical analyses (A and B). The photos of syncytia forma- tion were taken at 18 h after coculture and presented (C). (D and E) Effect of COVID-19 sera on cell-to-cell and cell-free infection of SARS-CoV-2 and SARS-CoV. Experiments were performed as described as above, except five diluted COVID-19 sera were included during the infection period. Effect on cell-to-cell (D) and cell-free (E) infection of SARS-CoV or SARS-CoV-2 were summarized and plotted by setting the values of mock infection control to 100% (n = ~3 to 4). PV, pseudotyped virus. **P<0.01, ***P<0.001. ns, not significant.
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