How does HbS aggregation occur in sickle-cell anemia? Place the steps in the correct order. Note that deoxyhemoglobin is inthe T state; oxyhemoglobin is in the R state.No aggregationR state Hb shifts to T state Hb.Sickled red blood cellAnswer BankVal interacts with the pocket of a ß chain on another HbS.Additional T state HbS interact with the growing aggregate to form an insoluble fiber.[0₂] decreases due to vigorous exercise or high altitude.

Sickling is seen in sickle cell anaemia where haemoglobin inside the RBC cells sticks together and…

Answered: How does HbS aggregation occur in…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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With the disruption of PDHC activity, TCA cycle is also effected. which of the following intermediates have a high probability of being produced from other pathways/processes in a cell during sepsis? Group of answer choices Malate Acetyl-CoA Succinate Ketone bodies Fumerate Citrate Succinly-CoA
Read Section 3 to 3.5 and answer the ff: -What biomolecule contains the genetic information of SARS-CoV-2? Be specific. -Describe the structure of the SARS-CoV-2. -What are the four main structural proteins in SARS-CoV-2? Briefly explain what each protein does. -How does SARS-CoV-2 bind to the host cell? Provide some evidences to support your answer. -What proteins can be targeted for therapeutic purposes (i.e. vaccines or antiviral drugs)?
Nearly all immune deficiency diseases that result in impaired TH17 and ILC3 function lead to chronic mucocutaneous candidiasis (CMC), usually accompanied by increased susceptibility to pyogenic bacterial infections. However, a subset of these patients also show increased susceptibility to intracellular bacterial infections, such as those caused by Mycobacteria species. What is the explanation for why some, but not all, of these patients have increased susceptibility to intracellular bacteria and which patients fall into this category?
Can you please answer these two sub questions and explains please
Some studies have shown that cholesterol plays an important role in the entry of SARS-CoV-2 into human cells. Please develop a hypothesis explaining this observation. Be as specific as possible in your explanation of your hypothesis.
Which of the following pairs is mismatched? a. effector memory γ:δ T cells; CD45RA b. splenic γ:δ T cells; Vδ1 c. naive γ:δ T cells; CD27 d. isopentyl pyrophosphate; self phosphoantigen e. hydroxyl-methyl-but-2-enyl-pyrophosphate; BTN3A1 f. glucose monomycolate; Mycobacterium phlei.
A T cell can have TCRs with two different alpha chains. Explain how this can occur and why we typically only see mature T cells with one alpha chain.
Class I major histocompatibility complex molecules are found on O all anucleated cells. O antigen-presenting O all nucleated O None of the choices are correct. QUESTION 67 Important characteristics of antimicrobic drugs include O readily delivered to the site of infection. O high toxicity against microbial cells. O remains active in body tissues and fluids. do not cause serious side effects in humans. O All of these choices are correct. QUESTION 68 Antibodies O can bind to an immunogen. O are part of the nonspecific immune response. O can target the immunogen for destruction. O both can bind to an immunogen and can target the immunogen for destruction. O both can bind to an immunogen and are part of the nonspecific immune response.
Addition of immunoglobulin G (IgG) specific for hemoglobin to a solution of hemoglobin results in the formation of a red precipitate. In contrast, addition of the Fab fragments from this antibody to hemoglobin results in no such precipitate. What could explain this difference in results? Treatment with papain produces Fab fragments with different antigen specificity than the original IgG molecule. IgG can simultaneously bind two different antigens, whereas an Fab fragment can only bind one antigen at a time. The Fab fragments preferentially bind to other Fab fragments rather than to hemoglobin. The hemoglobin molecule antibody-binding sites can bind IgG molecules, but cannot bind Fab fragments.

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