Answered: With the disruption of PDHC activity,…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

With the disruption of PDHC activity, TCA cycle is also effected. which of the following intermediates have a high probability of being produced from other pathways/processes in a cell during sepsis? Group of answer choices Malate Acetyl-CoA Succinate Ketone bodies Fumerate Citrate Succinly-CoA

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Expert Solution

Step 1: impact of sepsis on the Tricarboxylic Acid (TCA) cycle

A grave medical illness called sepsis is marked by an excessive immunological reaction to an infection, which can impair regular cellular processes.

The Pyruvate Dehydrogenase Complex (PDHC) activity is disrupted in this situation, and several TCA cycle intermediates are impacted.

Understanding the metabolic alterations which take place amid this serious medical condition and its broader consequences in cellular biochemistry is essential. Sepsis impacts the formation of TCA cycle intermediates.