The tertiary structure of gp120 is shown below. Please describe the protein (make sure to cover primary, secondary, and tertiary levels).

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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protein. Hypothesize what type of amino acid R groups you might find on the ii)
exterior regions of each of these proteins, iii) and on the membrane bound portion
of these proteins.
b) The tertiary structure of gp120 is shown below. Please describe the protein (make
sure to cover primary, secondary, and tertiary levels).
CDR H3
1FD6 scaffold
Asn 160 glycan
CDR L3
CDR L1
CDR L2
PG9 light chain
CAP45 V1/V2
V2 loop
V1 loop
Asn 156 glycan
CDR H2
CDR H1
PG9 heavy chain
Transcribed Image Text:protein. Hypothesize what type of amino acid R groups you might find on the ii) exterior regions of each of these proteins, iii) and on the membrane bound portion of these proteins. b) The tertiary structure of gp120 is shown below. Please describe the protein (make sure to cover primary, secondary, and tertiary levels). CDR H3 1FD6 scaffold Asn 160 glycan CDR L3 CDR L1 CDR L2 PG9 light chain CAP45 V1/V2 V2 loop V1 loop Asn 156 glycan CDR H2 CDR H1 PG9 heavy chain
1. Glycoproteins coat the outside of viruses; in particular they are important in
helping HIV dock to our cells and also help the virus evade our immune system.
Below is an image of the HIV transmembrane gp120 protein docking to human cd4
cells via the CXCR4 receptor.
HIV-gp120
HIV
CXCR4
Coreceptor
CCR5
Coreceptor
CD4
Receptor
CD4 Cell
a) i) Describe the general chemical interactions that might be involved in protein-
protein interactions between the HIV gp120 protein and the human cd4 CXCR4
protein. Hypothesize what type of amino acid R groups you might find on the ii)
exterior regions of each of these proteins, iii) and on the membrane bound portion
of these proteins.
b) The tertiary structure of gp120 is shown below. Please describe the protein (make
sure to cover primary, secondary, and tertiary levels).
Transcribed Image Text:1. Glycoproteins coat the outside of viruses; in particular they are important in helping HIV dock to our cells and also help the virus evade our immune system. Below is an image of the HIV transmembrane gp120 protein docking to human cd4 cells via the CXCR4 receptor. HIV-gp120 HIV CXCR4 Coreceptor CCR5 Coreceptor CD4 Receptor CD4 Cell a) i) Describe the general chemical interactions that might be involved in protein- protein interactions between the HIV gp120 protein and the human cd4 CXCR4 protein. Hypothesize what type of amino acid R groups you might find on the ii) exterior regions of each of these proteins, iii) and on the membrane bound portion of these proteins. b) The tertiary structure of gp120 is shown below. Please describe the protein (make sure to cover primary, secondary, and tertiary levels).
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