Name two possible functions of CD8a+ dendritic cells that could account for the results seen in the Batf3-/- mice immunized with WNV.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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An experiment is performed in a mice and studies have indicated that Batf3-/- mice lack one particular subset of conventional dendritic cells, known as CD8a+ dendritic cells (DC), but otherwise appear to have normal numbers and subsets of all other immune cell populations (e.g., T cells, B cells, macrophages, etc.). The results of this experiment are shown in the figure below.  Name two possible functions of CD8a+ dendritic cells that could account for the results seen in the Batf3-/- mice immunized with WNV.

Left popliteal lymph node
Wild-type
Batf3--
I.
105 -
104-
103-
P33 ova
P33 ova
Number of IFN-y+ CD8 T cells
Transcribed Image Text:Left popliteal lymph node Wild-type Batf3-- I. 105 - 104- 103- P33 ova P33 ova Number of IFN-y+ CD8 T cells
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