Wiskott–Aldrich syndrome is an immunodeficiency disease due to mutations in the gene encoding WASp. Individuals with this disease make poor antibody responses to protein antigens, due to impaired T cell help for B cells. WASp-deficient T cells are likely impaired in providing adequate help to B cells due to: A. Defects in up-regulating expression of genes encoding cytokines required by B cells B. Defects in up-regulating metabolic pathways for T cell macromolecular synthesis C. Defects in up-regulating expression of genes needed for T cell survival D. Defects in cytoskeletal reorganization needed for directed T cell cytokine secretion
Wiskott–Aldrich syndrome is an immunodeficiency disease due to mutations in the gene encoding WASp. Individuals with this disease make poor antibody responses to protein antigens, due to impaired T cell help for B cells. WASp-deficient T cells are likely impaired in providing adequate help to B cells due to:
A. Defects in up-regulating expression of genes encoding cytokines required by B cells
B. Defects in up-regulating
C. Defects in up-regulating expression of genes needed for T cell survival
D. Defects in cytoskeletal reorganization needed for directed T cell cytokine secretion
E. Defects in up-regulating T cell integrin adhesion for stable interactions with B cells
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