B-cell development in the bone marrow is an inherently wasteful process. Nearly half of the pro-B cells produced will die without progressing to the next stage of development. This massive loss of pro-B cells is due to O detrimental DJH rearrangements on both alleles of the immunoglobulin heavy-chain locus. the failure of the pro-B cell to make a complete immunoglobulin heavy-chain protein. the inability of many pro-B cells to proceed with rearranging a VH to their rearranged DJH sequence. O the failure of many pro-B cells to up-regulate Pax5 and become committed to the B-cell lineage.
B-cell development in the bone marrow is an inherently wasteful process. Nearly half of the pro-B cells produced will die without progressing to the next stage of development. This massive loss of pro-B cells is due to O detrimental DJH rearrangements on both alleles of the immunoglobulin heavy-chain locus. the failure of the pro-B cell to make a complete immunoglobulin heavy-chain protein. the inability of many pro-B cells to proceed with rearranging a VH to their rearranged DJH sequence. O the failure of many pro-B cells to up-regulate Pax5 and become committed to the B-cell lineage.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:B-cell development in the bone marrow is an inherently wasteful process. Nearly half of the pro-B cells produced will die without
progressing to the next stage of development. This massive loss of pro-B cells is due to
detrimental DJH rearrangements on both alleles of the immunoglobulin heavy-chain locus.
the failure of the pro-B cell to make a complete immunoglobulin heavy-chain protein.
the inability of many pro-B cells to proceed with rearranging a V₁ to their rearranged DJH sequence.
the failure of many pro-B cells to up-regulate Pax5 and become committed to the B-cell lineage.
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