Answered: True or False: The class switch…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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1. True or False: Negative selection of transitional B cells in the spleen removes B cell clones whose BCR recognizes self antigens that weren't expressed in the bone marrow.

2. Which of the following statements about the pre-BCR is false?

A. Transiently expressed with the IgM isotype in its constant region.

B. Signals in an antigen-independent manner.

C. Consists of a rearranged immunoglobulin light chain paired with a surrogate immunoglobulin heavy chain (VpreB).

D. Consists of a rearranged immunoglobulin heavy chain paired with a surrogate light chain (VpreB + lambda5)

3. True or False: The class switch recombination of IgA antibodies is induced by TGF-beta or IL-21, and IgA antibodies can be transported across the placental interface as pentameric (5 member) oligomers.

4. A newborn infant has not started breastfeeding yet. Which isotype of maternal antibody/antibodies does the newborn have that they received from their mother while in utero?

A. IgD only

B. IgA only

C. IgG and IgA

D. IgE only

E. IgG only

5. Which of the following statements about the enzyme activation-induced cytidine deaminase (AID) is true?

A. Can trigger both DNA mismatch repair and DNA base-excision repair pathways

B. All of these statements are true.

C. Attacks single-stranded DNA to convert cytidine into uridine

D. Required for both somatic hypermutation and class-switch recombination in germinal center B cellS

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