2. The following is false about the junctional diversity of antibodies? A. insertion of none-coded nucleotides to the ends B. Insertion of pallindromic nucleotides to both ends C. TdT adds or remove nucleotides at the exposed ends of the V, D or J genes D. occurs exclusively in all lymphocytes including NK cells
2. The following is false about the junctional diversity of antibodies? A. insertion of none-coded nucleotides to the ends B. Insertion of pallindromic nucleotides to both ends C. TdT adds or remove nucleotides at the exposed ends of the V, D or J genes D. occurs exclusively in all lymphocytes including NK cells
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:2. The following is false about the junctional diversity of antibodies?
A. insertion of none-coded nucleotides to the ends
B. Insertion of pallindromic nucleotides to both ends
C. TdT adds or remove nucleotides at the exposed ends of the V, D or J genes
D. occurs exclusively in all lymphocytes including NK cells
3. The following is false about somatic hypermutation?
A Are not transmitted to offspring
B occurs in all T cells
C occurs only within germinal centers
D Activation-induced cytidine deaminase plays an important role
E occurs in variable regions CDR hotspots of Ig genes H and L chains
Expert Solution
Step 1
V(D)J recombination is the type of somatic recombination in immune cells like lymphocytes. This is required for the antigen receptor to be unique. The VDJ stands for variability, diversity, and joining.
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