4. Both the constant domains and variable domains of immunoglobulins are formed by beta-barrels. For each type of barrel briefly describe the following: a. How the barrels from the heavy and light chains interact b. The relative structure and significance of the loops between the beta strands c. For the variable domain barrels, explain how the antigen binding site is formed 5. Compare and contrast the structure and function of MHC I and MHC II. 6. What are the specific physiological functions of myoglobin and hemoglobin? How does their sensitivity to fluctuations in oxygen concentrations facilitate their function?

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