Genetic factors contribute to the development of IgE-mediated allergic disease.  Genetic studies have identified more than 40 genes that show allelic variations associated with the development of allergic asthma and atopic

Q: For identical twins, if one of them develops the autoimmune disorder because of genetic reason, does…

A: Identical twins are always of same-sex, blood type and share all of their genes as they receive…

Q: what is the diagnosis of Chronic granulomatous disease (CGD) and explain the genetic mechanism…

A: Bridges-Good syndrome is another name for chronic granulomatous disease (CGD). The distinctive…

Q: The Bcl-2 protein was initially discovered via its ability to contribute to progression of B-cells…

A: Cancer is a disease caused by abnormal cell division.

Q: 1. Diagram the steps of TH cell activation. Is IL-2 required for this process? What is the source of…

A:

Q: Why is the agglutination seen in Rh finer than that seen in groups A and B?

A: If you have blood group test if the blood is showing agglutination  then It is RH positive and if…

Q: Match the following terms of B-cell development with the best definition. Surrogate light chain…

A: The immune system of the body is the vital system that provides protection to the body against…

Q: Name Pancytokeratin (CK) Vimentin Photomicrographs of marker expression Task Mark on the picture: 1-…

A: Immunohistochemistry- Immunohistochemistry is simply the biological application of immunostaining…

Q: 8) In addition to the ABO self-antigen system, another red blood cell self-antigen system is the Rh…

A: Many characteristics in humans and other living organisms are ultimately determined by the…

Q: A. In general, which genes have been found to correlate best with susceptibility or resistance to…

A: Autoimmune diseases are diseases in which the body's immune system starts to attack its cells and…

Q: For the following mechanism that is thought to contribute to maternal–fetal tolerance, state whether…

A: Adaptive immunity has two division, cell-mediated immunity and humoral immunity. Humoral immunity…

Q: Ataxia-telangiectasis (ATM) is a rare genetic neurodegenerative disease. About 20% of people with…

A: Ataxia-telangiectasia ( A-T) is caused by mutations in the ATM (ATM serine/threonine kinase or…

Q: (a) Identify both the cellular component and the location of the component that is responsible for…

A: Luciferase reporter produces luminescence. If cells contain a luciferase vector, the luminescent…

Q: Define polymorphism and polygeny as they apply to MHC genes.

A: Genes are the basic structural and functional unit of heredity. They carry coded genetic information…

Q: cells? (b) What are the (c) By what mech Hfr cells to F+ ce

A:

Q: Flow cytometry analysis was performed on the blood of an individual known to have been recently…

A: Rhino virus: it causes common cold, pneumonia in children.  Mycobacterium: it causes tuberculosis.…

Q: 1- B cell clones undergo somatic hypermutation in which structure? Group of answer choices A) Thymic…

A: Progenitor cells are types of stem cells that are able to differentiate into specialized cell types.…

Q: The adaptive immune system uses multiple strategies to generate diversity in our ability to mount…

A: Adaptive immunity is made up of two main components: T cells and B cells. An immune system that…

Q: For sickle cell anemia: a) Description of the phenotype b) Description of the genetics of…

A: Sickle cell anemia is one of a group of disorders known as sickle cell disease. Sickle cell anemia…

Q: It has been suggested that complexes of IgE with allergen can be transferred from mother to child…

A: An Allergic infant will normally have symptoms in several body systems. An increased immunoglobulin…

Q: To study the immune responses that provide protection against tumor growth in mice, some…

A: Cytokines are immunological molecules present in biological systems that are important for cell…

Q: a) How does Venetoclax, a BH3 mimetic, function in increasing cellular death? In your answer make…

A: Venetoclax attaches to a protein called Bcl-2. This protein is present in high amounts in CLL cancer…

Q: a) Mention the TNM classification of Cancer.?

A: Cancer is a significant health concern worldwide and can have a profound impact on an individual's…

Q: Alpha-1 antitrypsin has codominant inheritance. M genes express normal levels. S and Z genes have…

A: Emphysema is caused by deficiency in Alpha 1 antitrypsin.This disorder causes lung diseases and…

Q: Antibody heavy and light chain polypeptides consist of repeated domains, each of which is ~110 amino…

A: The immune system of the human body consists of specialized cells, proteins, tissues, and organs to…

Q: Describe examples that explain the molecular mechanismsof epistasis, complementation, gene modifier…

A: Gene interaction is a condition in which one or more genes affect the phenotype of an organism. It…

Q: Individuals who express HLA-B27 are 90 times more likely to develop the autoimmune disorder…

A: HLA-B27 is called human leukocyte antigen B27 (HLA-B27). Human leukocyte antigens (HLAs) are…

Q: Name two main pathways that macrophages contribute to the innate immune response. For each of these…

A: Natural defense, or indirect protection, is the innate immune system unlike adaptive immune system…

Q: Explain the following statements in 4-6 lines each:   Premalignant (hyperplastic or dysplastic)…

A: Premalignant cells are also known as precancerous cells. These are the abnormal cells that have the…

Q: dentify two genetic mechanisms whereby proto-oncogenes can become overexpressed.Select the two…

A: Activation of Proto-oncogenes. Proto-oncogenes are normal cell proliferating genes that encode cell…

Q: Individuals who express HLA-B27 are 90 times more likely to develop the autoimmune disorder…

A: Human Leukocyte Antigen B27 or HLA-B27 is a kind of antigen categorized into class I of antigen and…

Q: In a Cervical Cancer screening program, 500 asymptomatic women were examined using the Pap smear…

A: Cervical Cancer screening program is a screening test for testing women who are at risk of cervical…

Q: During the early developmental stages of α:β T cells in the thymus, there are two key checkpoints…

A: The T cells are mainly derived from hematopoietic stem cells present in the bone marrow. The…

Q: shows the directed migration of two immune cell types, neutrophils (red) and macrophages (green) to…

A: Immune cells are the sort of cells that emerge from stem cells in the bone marrow and mature into…

Q: . What are the number of total chromosomes that carries the genes encoding heavy and light chain…

A: Introduction :- Immunoglobulins or antibody are made up of two light chains and two heavy chains of…

Q: Why is this ligand for the NK-cell receptor CD94:NKG2A. considered a broad mechanism for the NK-cell…

A: NKT cells exhibit a wide range of receptors and kill the infected body cells and tumor cells.

Q: 1. Review the following link (don't get caught up in details) to determine if our immune cells use…

A: Chemical signaling is a type of signaling which involves molecules. It is a type of cell signaling.…

Q: Briefly describe the effector functions and mediators of the following CD4 T lymphocyte subsets.…

A: When B cell presenting antigen through MHC class II molecule, TH Cell recognise it. T helper cell…

Q: What is the role of genomics in generating anti-SEMA3A monoclonal antibodies as a potential…

A: Genomics is the study of whole genetic component of an organism(genome) . This helps in identifying…

Q: Hyper-IgE syndrome, also known as Job’s syndrome, is an immunodeficiency disease resulting from the…

A: Job's Syndrome

Q: Toll-like receptors represent an ancient pathogen-recognition system. The first pattern recognition…

A: The recent advancement of science has led to the discovery of the Toll-like receptors (TLRs) that…

Immune Disorders

The collaboration between the cells and proteins that work together as a defense system against infection comprises the immune system.Each of them performs a variety of tasks to recognize and/or react against a foreign body.