The TNF family of cytokines and their receptors are critical for the development of secondary lymphoid organs, such as the lymph nodes and Peyer’s patches. As a consequence, knockout mice lacking expression of LT-b fail to develop most of these structures. Reconstitution of irradiated LT-b-deficient mice with bone marrow stem cells from wild-type mice (e.g., LT-b-sufficient) would:Restore all missing lymphoid structures in the recipient miceRestore the missing lymphoid structures but not the missing follicular dendritic cells in the recipient miceRestore the missing follicular dendritic cells but not the missing lymphoid structures in the recipient miceHave no effect on any lymphoid structures in the recipient miceOnly restore the proper organization of B cell follicles in the recipient mice

Lymph nodes, tonsils, Peyer's patches, spleen, adenoids, skin, and mucosa-associated lymphoid tissue…

Answered: The TNF family of cytokines and their…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The TNF family of cytokines and their receptors are critical for the development of secondary lymphoid organs, such as the lymph nodes and Peyer’s patches. As a consequence, knockout mice lacking expression of LT-b fail to develop most of these structures. Reconstitution of irradiated LT-b-deficient mice with bone marrow stem cells from wild-type mice (e.g., LT-b-sufficient) would:

Restore all missing lymphoid structures in the recipient mice
Restore the missing lymphoid structures but not the missing follicular dendritic cells in the recipient mice
Restore the missing follicular dendritic cells but not the missing lymphoid structures in the recipient mice
Have no effect on any lymphoid structures in the recipient mice
Only restore the proper organization of B cell follicles in the recipient mice

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