Normal CD8--T-cell receptor cytoplasmic proteins- -мНС class I molecule All nucleated cells present peptides from cytoplasmic proteins on MHC class I molecules. Tc cells do not recognize peptides presented by healthy "self" cell. (a) -Virus Viral- proteins Cytokines Targeted delivery of a "death package" FIGURE 15.21 Functions of Tc Cells (a) Tc cells ignore healthy "self" cells. (b) Tc cells induce apoptosis in virally infected "self" cells. Virally infected "self" cells present viral peptides on MHC class I molecules. Tc cell recognizes viral peptide presented by an infected "self" cell and initiates apoptosis in that target. It also releases cytokines that alert neighboring cells. Target cell undergoes apoptosis. (b) ww -
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
Could a TC cell induce apoptosis in a “self” cell that lost the ability to produce MHC class I molecules?
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