A metabolically stressed epithelial cell expresses the protein MICits surface and then interacts with a natural killer (NK) cell. What is the outcome of this interaction?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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A metabolically stressed epithelial cell expresses the protein MICits surface and then interacts with a natural killer (NK) cell. What is the outcome of this interaction?

 

A. MIC-A binds to NKG2D but is overruled by inhibitory receptors on the NK cell that bind to MHC-on the epithelial cells epithelial cell survives

 

B. MIC-A binds to NKG2D, which activates the NK cell through sensing of "stress-induced The cell then kills the epithelial cell via apoptosis

 

C. MIC-A binds to NKG2AInhibiting NK cell activation. The epithelial cell survives

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